Activation of IFN-γ/STAT/IRF-1 in Hepatic Responses to Klebsiella pneumoniae Infection

• Published in: PloS one Vol. 8; no. 11; p. e79961
• Main Authors: Lin, Yi-Chun, Lu, Min-Chi, Lin, Chingju, Chiang, Ming-Ko, Jan, Ming-Shiou, Tang, Hui-Ling, Liu, Hsu-Chung, Lin, Wea-Lung, Huang, Chih-Yang, Chen, Chuan-Mu, Lai, Yi-Chyi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.11.2013; Public Library of Science (PLoS)
• Subjects: Activation; Age; Agricultural biotechnology; Animals; Apoptosis; Bioluminescence; Caspase; Caspase 3 - metabolism; Caspase-3; Cell cycle; Chemokine CXCL2 - metabolism; Cytokines; Diabetes; Diabetes mellitus; E coli; Endoplasmic reticulum; Escherichia coli; Hepatocytes; Hospitals; IL-1β; Immunology; Infections; Infectious diseases; Insulin; Interferon; Interferon regulatory factor; Interferon regulatory factor 1; Interferon Regulatory Factor-1 - metabolism; Interferon-gamma - metabolism; Interleukin-1beta - metabolism; Internal medicine; Intestine; Klebsiella; Klebsiella Infections - metabolism; Klebsiella pneumoniae; Klebsiella pneumoniae - pathogenicity; Leukocytes (neutrophilic); Life sciences; Liver; Liver - metabolism; Male; Medicine; Meningitis; Metabolic disorders; Metastasis; Mice; Mice, Inbred BALB C; Morbidity; Neutrophils; Organs; Pathogenesis; Physiology; Pneumonia; Proteins; Rodents; Signaling; Transcription factors; Transducers; Translocation; γ-Interferon; China; Taiwan

Klebsiella pneumoniae-caused liver abscess (KLA) has become a health problem in Taiwan and is continually reported in other countries. Diabetes mellitus, the most common metabolic disorder, underlies half of the KLA patients in Taiwan. The clinical impact of KLA has been well-documented. Nevertheles...