A novel form of progressive retinal atrophy in Swedish vallhund dogs

• Published in: PloS one Vol. 9; no. 9; p. e106610
• Main Authors: Cooper, Ann E, Ahonen, Saija, Rowlan, Jessica S, Duncan, Alison, Seppälä, Eija H, Vanhapelto, Päivi, Lohi, Hannes, Komáromy, András M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.09.2014; Public Library of Science (PLoS)
• Subjects: Age; Animal models; Animals; Atrophy; Biology and Life Sciences; Blindness; Continents; Discoloration; Disease Progression; Dog Diseases - pathology; Dog Diseases - physiopathology; Dogs; Electroretinography; Epithelium; Female; Genotypes; Heredity; Macular degeneration; Male; Medicine and Health Sciences; Mutation; Pedigree; Phenotype; Phenotypes; Retina; Retinal degeneration; Retinal Diseases - pathology; Retinal Diseases - physiopathology; Retinal Diseases - veterinary; Retinal pigment epithelium; Retinitis; Retinitis pigmentosa; Sweden; Veterinary colleges; Vision; Sweden; Canada; East Lansing Michigan; United States > US; Japan; Finland; California; Germany; Pennsylvania; Michigan

Inherited retinal degenerations, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent leading causes of incurable blindness in humans. This is also true in dogs, where the term progressive retinal atrophy (PRA) is used to describe inherited photoreceptor degenerati...