Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway - Yuan, Bin; El Dana, Fouad; Ly, Stanley; Yan, Yuanqing; Ruvolo, Vivian; Shpall, Elizabeth J.; Konopleva, Marina; Andreeff, Michael; Battula, Venkata Lokesh (PloS one, 2020)
Keywords: Acute myeloid leukemia; Aldehyde dehydrogenase; Aldehyde Dehydrogenase - genetics; Aldehydes; Antibodies; Biology and life sciences; Bone marrow; Cancer therapies; Cell Line, Tumor; Cell Proliferation - drug effects; Chemoresistance; Chemotherapy; Coculture Techniques; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Gene sequencing; Genotype & phenotype; Growth factors; HEK293 Cells; Hematology; Humans; Isoforms; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; Leukemogenesis; Medicine and Health Sciences; Mesenchymal stem cells; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - pathology; Mesenchyme; Myeloid leukemia; Oxidoreductases Acting on CH-NH Group Donors - genetics; p38 Mitogen-Activated Protein Kinases - genetics; Patients; Phenotypes; Proteins; Ribonucleic acid; RNA; Signal Transduction - drug effects; Stem cells; Stromal cells; Transcription factors; Transforming Growth Factor beta1 - genetics; Transforming growth factor-b1; Tumor Microenvironment - genetics; Canada; United States--US; Texas