Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine

• Published in: PloS one Vol. 10; no. 7; p. e0132003
• Main Authors: Li, Lei, Honda-Okubo, Yoshikazu, Li, Connie, Sajkov, Dimitar, Petrovsky, Nikolai
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.07.2015; Public Library of Science (PLoS)
• Subjects: Activation-induced cytidine deaminase; Adjuvants; Adult; Affinity; Aged; Aged, 80 and over; Animal models; Antibody Affinity - drug effects; Antibody Affinity - immunology; Antibody Formation - drug effects; Antigens; Avidity; B-cell receptor; Clinical trials; Combined vaccines; Complementarity Determining Regions - genetics; Complementarity Determining Regions - immunology; Complementarity-determining region 3; Cryopreservation; Cytidine deaminase; Cytidine Deaminase - metabolism; Deoxyribonucleic acid; DNA; Encephalitis; Female; Gene expression; Hepatitis; Human behavior; Humans; Immunity; Immunization; Immunogenicity; Immunoglobulin G - immunology; Immunoglobulins; Influenza; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza Vaccines - pharmacology; Inulin; Inulin - administration & dosage; Inulin - analogs & derivatives; Inulin - pharmacology; Lymphocytes; Lymphocytes B; Male; Maturation; Medical research; Middle Aged; Mutagenesis; Mutation; Mutation - genetics; Pandemics; Peripheral blood; Plasma Cells - drug effects; Plasma Cells - immunology; Receptors, Antigen, B-Cell - metabolism; Seasons; T cell receptors; Vaccination; Vaccines; Viruses; Young Adult

There is a major need for new adjuvants to improve the efficacy of seasonal and pandemic influenza vaccines. Advax is a novel polysaccharide adjuvant based on delta inulin that has been shown to enhance the immunogenicity of influenza vaccine in animal models and human clinical trials. To better und...