Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-α and IDO Activation

• Published in: PloS one Vol. 10; no. 6; p. e0128439
• Main Authors: Bandeira, Luana Graziella, Bortolot, Beatriz Salari, Cecatto, Matheus Jorand, Monte-Alto-Costa, Andréa, Romana-Souza, Bruna
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.06.2015; Public Library of Science (PLoS)
• Subjects: AKT protein; Animals; Catabolism; Cell culture; Cell migration; Collagen; Collagen - genetics; Collagen - metabolism; Contraction; Cytokines; Dioxygenase; Embryology; Epinephrine; Euthanasia; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene expression; Histology; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation; Inflammatory response; Inhibition; Kinases; Laboratories; Lesions; Leukocyte migration; Leukocytes (neutrophilic); Lipid Peroxidation; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; Metanephrine - blood; Mice; Neutrophils - drug effects; Neutrophils - metabolism; Peroxidation; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Re-Epithelialization; Reduction; Rodents; Skin; Skin - drug effects; Skin - injuries; Skin - metabolism; Stress; Stress, Psychological - metabolism; Stress, Psychological - pathology; Stresses; Studies; Tryptophan; Tryptophan - blood; Tryptophan - pharmacology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Wound healing; Brazil; Rio de Janeiro Brazil

Stress prolongs the inflammatory response compromising the dermal reconstruction and wound closure. Acute stress-induced inflammation increases indoleamine 2, 3-dioxygenase-stimulated tryptophan catabolism. To investigate the role of indoleamine 2, 3-dioxygenase expression and tryptophan administrat...