Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors

• Published in: PloS one Vol. 11; no. 2; p. e0148564
• Main Authors: Phanthanawiboon, Supranee, Limkittikul, Kriengsak, Sakai, Yusuke, Takakura, Nobuyuki, Saijo, Masayuki, Kurosu, Takeshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.02.2016; Public Library of Science (PLoS)
• Subjects: Acute Disease; Angiopoietin; Angiopoietins - metabolism; Angiopoietins - pharmacology; Animal models; Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Neutralizing - pharmacology; Biology and Life Sciences; Biomarkers; Blood vessels; Capillary Permeability; Cytokines - blood; Cytokines - genetics; Cytokines - metabolism; Dengue; Dengue - genetics; Dengue - metabolism; Dengue - mortality; Dengue - virology; Dengue fever; Dengue hemorrhagic fever; Dengue Virus; Disease Models, Animal; Disseminated infection; Flavivirus; Gene Expression; Hemorrhage; Infections; Infectious diseases; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Interferon; Interferon receptors; Interleukin 6; Kidneys; Laboratory animals; Leakage; Liver; Liver - metabolism; Liver - pathology; Liver Function Tests; Medical research; Medicine and Health Sciences; Mice; Mice, Knockout; Monocyte chemoattractant protein 1; mRNA; Necrosis; Neutralizing; Pathogenesis; Proteins; Receptor, TIE-2 - metabolism; Receptors; Receptors, Interferon - deficiency; Research and Analysis Methods; Rodents; Signal Transduction; Signaling; Small intestine; Survival; Systemic diseases; Thrombocytopenia - etiology; Tropical diseases; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vaccines; Vector-borne diseases; Veterinary medicine; Viral diseases; Viral Load; Virology; Viruses; West Nile virus; α-Interferon; γ-Interferon; Thailand; Japan

Severe dengue is caused by host responses to viral infection, but the pathogenesis remains unknown. This is, in part, due to the lack of suitable animal models. Here, we report a non-mouse-adapted low-passage DENV-3 clinical isolate, DV3P12/08, derived from recently infected patients. DV3P12/08 caus...