Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors - Phanthanawiboon, Supranee; Limkittikul, Kriengsak; Sakai, Yusuke; Takakura, Nobuyuki; Saijo, Masayuki; Kurosu, Takeshi (PloS one, 2016)
Keywords: Acute Disease; Angiopoietin; Angiopoietins - metabolism; Angiopoietins - pharmacology; Animal models; Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Neutralizing - pharmacology; Biology and Life Sciences; Biomarkers; Blood vessels; Capillary Permeability; Cytokines - blood; Cytokines - genetics; Cytokines - metabolism; Dengue; Dengue - genetics; Dengue - metabolism; Dengue - mortality; Dengue - virology; Dengue fever; Dengue hemorrhagic fever; Dengue Virus; Disease Models, Animal; Disseminated infection; Flavivirus; Gene Expression; Hemorrhage; Infections; Infectious diseases; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Interferon; Interferon receptors; Interleukin 6; Kidneys; Laboratory animals; Leakage; Liver; Liver - metabolism; Liver - pathology; Liver Function Tests; Medical research; Medicine and Health Sciences; Mice; Mice, Knockout; Monocyte chemoattractant protein 1; mRNA; Necrosis; Neutralizing; Pathogenesis; Proteins; Receptor, TIE-2 - metabolism; Receptors; Receptors, Interferon - deficiency; Research and Analysis Methods; Rodents; Signal Transduction; Signaling; Small intestine; Survival; Systemic diseases; Thrombocytopenia - etiology; Tropical diseases; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vaccines; Vector-borne diseases; Veterinary medicine; Viral diseases; Viral Load; Virology; Viruses; West Nile virus; α-Interferon; γ-Interferon; Thailand; Japan