Characterization and Molecular Mechanism of AroP as an Aromatic Amino Acid and Histidine Transporter in Corynebacterium glutamicum

• Published in: Journal of Bacteriology Vol. 195; no. 23; pp. 5334 - 5342
• Main Authors: Shang, Xiuling, Zhang, Yun, Zhang, Guoqiang, Chai, Xin, Deng, Aihua, Liang, Yong, Wen, Tingyi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.12.2013
• Subjects: Amino Acid Transport Systems - genetics; Amino Acid Transport Systems - metabolism; amino acid transporters; Amino acids; Amino Acids - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Binding sites; Biosynthesis; Correlation analysis; Corynebacterium glutamicum; Corynebacterium glutamicum - genetics; Corynebacterium glutamicum - metabolism; energy; Gene Expression Regulation, Bacterial - physiology; Gram-positive bacteria; histidine; hydrophobic bonding; missense mutation; Models, Molecular; phenylalanine; Phylogeny; Protein Binding; Protein Conformation; Substrates; tryptophan; tyrosine

Corynebacterium glutamicum is equipped with abundant membrane transporters to adapt to a changing environment. Many amino acid transporters have been identified in C. glutamicum, but histidine uptake has not been investigated in detail. Here, we identified the aromatic amino acid transporter encoded...