A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome

• Published in: PLoS pathogens Vol. 17; no. 2; p. e1008859
• Main Authors: Yoshikawa, Tomoki, Taniguchi, Satoshi, Kato, Hirofumi, Iwata-Yoshikawa, Naoko, Tani, Hideki, Kurosu, Takeshi, Fujii, Hikaru, Omura, Natsumi, Shibamura, Miho, Watanabe, Shumpei, Egawa, Kazutaka, Inagaki, Takuya, Sugimoto, Satoko, Phanthanawiboon, Supranee, Harada, Shizuko, Yamada, Souichi, Fukushi, Shuetsu, Morikawa, Shigeru, Nagata, Noriyo, Shimojima, Masayuki, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2021; Public Library of Science (PLoS)
• Subjects: Animal models; Antibodies; Antibody response; Biology and Life Sciences; Complications; Conjunctivitis; Deoxyribonucleic acid; DNA; DNA vaccines; Eczema; Encephalitis; Encephalopathy; Experiments; Fetuses; Fever; Gene expression; Genomes; Glycoproteins; GPC gene; Immunogenicity; Mammalian cells; Mammals; Medicine and Health Sciences; Microscopy; Polyclonal antibodies; Proteins; Research and Analysis Methods; RNA polymerase; Side effects; Skin diseases; Smallpox; Stomatitis; Strains (organisms); Thrombocytopenia; Vaccines; Viruses; Japan

Severe fever with thrombocytopenia syndrome (SFTS) caused by a species Dabie bandavirus (formerly SFTS virus [SFTSV]) is an emerging hemorrhagic infectious disease with a high case-fatality rate. One of the best strategies for preventing SFTS is to develop a vaccine, which is expected to induce both...