Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo
Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related facto...
Saved in:
Published in | Redox biology Vol. 64; p. 102783 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.08.2023
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is an essential transcription factor that defends against oxidative stress, and its function is negatively controlled by Kelch-like ECH-associated protein 1 (KEAP1). Therefore, activating NRF2 by inhibiting KEAP1 is viewed as a strategy for combating oxidative stress-related diseases. Here, we generated a cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC), which we named SD2267, that induces the proteasomal degradation of KEAP1 and leads to NRF2 activation. As was intended, SD2267 bound to KEAP1, recruited CRBN, and induced the degradation of KEAP1. Furthermore, the KEAP1 degradation efficacy of SD2267 was diminished by MG132 (a proteasomal degradation inhibitor) but not by chloroquine (an autophagy inhibitor), which suggested that KEAP1 degradation by SD2267 was proteasomal degradation-dependent and autophagy-independent. Following KEAP1 degradation, SD2267 induced the nuclear translocation of NRF2, which led to the expression of NRF2 target genes and attenuated ROS accumulation induced by acetaminophen (APAP) in hepatocytes. Based on in vivo pharmacokinetic study, SD2267 was injected intraperitoneally at 1 or 3 mg/kg in APAP-induced liver injury mouse model. We observed that SD2267 degraded hepatic KEAP1 and attenuated APAP-induced liver damage. Summarizing, we described the synthesis of a KEAP1-targeting PROTAC (SD2267) and its efficacy and mode of action in vitro and in vivo. The results obtained suggest that SD2267 could be used to treat hepatic diseases related to oxidative stress.
•SD2267 induced CRBN-mediated proteasomal degradation of KEAP1 in hepatocytes.•SD2267 translocated NRF2 into nucleus, and increased transcriptions of its target genes such as HMOX1, NQO1, GCLC and GCLM.•SD2267 alleviated acetaminophen-induced damages in vitro and in vivo.•This is the first time that PROTACs showed anti-oxidative effect in vivo. |
---|---|
AbstractList | Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is an essential transcription factor that defends against oxidative stress, and its function is negatively controlled by Kelch-like ECH-associated protein 1 (KEAP1). Therefore, activating NRF2 by inhibiting KEAP1 is viewed as a strategy for combating oxidative stress-related diseases. Here, we generated a cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC), which we named SD2267, that induces the proteasomal degradation of KEAP1 and leads to NRF2 activation. As was intended, SD2267 bound to KEAP1, recruited CRBN, and induced the degradation of KEAP1. Furthermore, the KEAP1 degradation efficacy of SD2267 was diminished by MG132 (a proteasomal degradation inhibitor) but not by chloroquine (an autophagy inhibitor), which suggested that KEAP1 degradation by SD2267 was proteasomal degradation-dependent and autophagy-independent. Following KEAP1 degradation, SD2267 induced the nuclear translocation of NRF2, which led to the expression of NRF2 target genes and attenuated ROS accumulation induced by acetaminophen (APAP) in hepatocytes. Based on in vivo pharmacokinetic study, SD2267 was injected intraperitoneally at 1 or 3 mg/kg in APAP-induced liver injury mouse model. We observed that SD2267 degraded hepatic KEAP1 and attenuated APAP-induced liver damage. Summarizing, we described the synthesis of a KEAP1-targeting PROTAC (SD2267) and its efficacy and mode of action in vitro and in vivo. The results obtained suggest that SD2267 could be used to treat hepatic diseases related to oxidative stress. Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is an essential transcription factor that defends against oxidative stress, and its function is negatively controlled by Kelch-like ECH-associated protein 1 (KEAP1). Therefore, activating NRF2 by inhibiting KEAP1 is viewed as a strategy for combating oxidative stress-related diseases. Here, we generated a cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC), which we named SD2267, that induces the proteasomal degradation of KEAP1 and leads to NRF2 activation. As was intended, SD2267 bound to KEAP1, recruited CRBN, and induced the degradation of KEAP1. Furthermore, the KEAP1 degradation efficacy of SD2267 was diminished by MG132 (a proteasomal degradation inhibitor) but not by chloroquine (an autophagy inhibitor), which suggested that KEAP1 degradation by SD2267 was proteasomal degradation-dependent and autophagy-independent. Following KEAP1 degradation, SD2267 induced the nuclear translocation of NRF2, which led to the expression of NRF2 target genes and attenuated ROS accumulation induced by acetaminophen (APAP) in hepatocytes. Based on in vivo pharmacokinetic study, SD2267 was injected intraperitoneally at 1 or 3 mg/kg in APAP-induced liver injury mouse model. We observed that SD2267 degraded hepatic KEAP1 and attenuated APAP-induced liver damage. Summarizing, we described the synthesis of a KEAP1-targeting PROTAC (SD2267) and its efficacy and mode of action in vitro and in vivo. The results obtained suggest that SD2267 could be used to treat hepatic diseases related to oxidative stress. •SD2267 induced CRBN-mediated proteasomal degradation of KEAP1 in hepatocytes.•SD2267 translocated NRF2 into nucleus, and increased transcriptions of its target genes such as HMOX1, NQO1, GCLC and GCLM.•SD2267 alleviated acetaminophen-induced damages in vitro and in vivo.•This is the first time that PROTACs showed anti-oxidative effect in vivo. Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination and prevention of excessive ROS are important aspects of preventing the development of such diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is an essential transcription factor that defends against oxidative stress, and its function is negatively controlled by Kelch-like ECH-associated protein 1 (KEAP1). Therefore, activating NRF2 by inhibiting KEAP1 is viewed as a strategy for combating oxidative stress-related diseases. Here, we generated a cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC), which we named SD2267 , that induces the proteasomal degradation of KEAP1 and leads to NRF2 activation. As was intended, SD2267 bound to KEAP1, recruited CRBN, and induced the degradation of KEAP1. Furthermore, the KEAP1 degradation efficacy of SD2267 was diminished by MG132 (a proteasomal degradation inhibitor) but not by chloroquine (an autophagy inhibitor), which suggested that KEAP1 degradation by SD2267 was proteasomal degradation-dependent and autophagy-independent. Following KEAP1 degradation, SD2267 induced the nuclear translocation of NRF2, which led to the expression of NRF2 target genes and attenuated ROS accumulation induced by acetaminophen (APAP) in hepatocytes. Based on in vivo pharmacokinetic study, SD2267 was injected intraperitoneally at 1 or 3 mg/kg in APAP-induced liver injury mouse model. We observed that SD2267 degraded hepatic KEAP1 and attenuated APAP-induced liver damage. Summarizing, we described the synthesis of a KEAP1-targeting PROTAC ( SD2267 ) and its efficacy and mode of action in vitro and in vivo . The results obtained suggest that SD2267 could be used to treat hepatic diseases related to oxidative stress. • SD2267 induced CRBN-mediated proteasomal degradation of KEAP1 in hepatocytes. • SD2267 translocated NRF2 into nucleus, and increased transcriptions of its target genes such as HMOX1 , NQO1 , GCLC and GCLM. • SD2267 alleviated acetaminophen-induced damages in vitro and in vivo. • This is the first time that PROTACs showed anti-oxidative effect in vivo. |
ArticleNumber | 102783 |
Author | Maeng, Han-Joo Oh, Seung Hyun Hwang, Jong-Ik Hwang, Jung Ho Kang, Ju-Hee Shin, Dongyun Zeb, Alam Jung, Hyun Jin Park, Se Yong Gurung, Raju Park, Sung Jean |
Author_xml | – sequence: 1 givenname: Se Yong surname: Park fullname: Park, Se Yong organization: College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea – sequence: 2 givenname: Raju surname: Gurung fullname: Gurung, Raju organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 3 givenname: Jung Ho surname: Hwang fullname: Hwang, Jung Ho organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 4 givenname: Ju-Hee surname: Kang fullname: Kang, Ju-Hee organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 5 givenname: Hyun Jin surname: Jung fullname: Jung, Hyun Jin organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 6 givenname: Alam surname: Zeb fullname: Zeb, Alam organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 7 givenname: Jong-Ik surname: Hwang fullname: Hwang, Jong-Ik organization: Graduate School of Medicine, Korea University, Seoul, Republic of Korea – sequence: 8 givenname: Sung Jean surname: Park fullname: Park, Sung Jean organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 9 givenname: Han-Joo surname: Maeng fullname: Maeng, Han-Joo organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 10 givenname: Dongyun surname: Shin fullname: Shin, Dongyun email: dyshin@gachon.ac.kr organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea – sequence: 11 givenname: Seung Hyun orcidid: 0000-0003-3678-2772 surname: Oh fullname: Oh, Seung Hyun email: eyeball@hanmail.net, eyeball@gachon.ac.kr organization: College of Pharmacy, Gachon University, Incheon, Republic of Korea |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37348157$$D View this record in MEDLINE/PubMed |
BookMark | eNp9UU1v1DAUtFARLaW_AAnlyCWLv-IkSAitlhZWVGoFPXGxHPt58SobB9sblX9fb1Oq9oIvzx7Pm_c08xodDX4AhN4SvCCYiA_bRQDjbxcUU5YRWjfsBTqhlLCSMlIfPbkfo7MYtzifpuGU4FfomNWMN6SqT9CvLzBB78cdDKnwtvh-vrwmZVJhA8kNm-L6x9XNclWowRQuxVyT87fO5FqMwY8QkoP4sVgPxeRS8DPx8Jj8G_TSqj7C2UM9RT8vzm9W38rLq6_r1fKy1BUVqTS8o6IRtW65sdQ0WBmBsa3qDroGrFUETG1YC4ppjFnHMkYwa1lHoDLsFK1nVePVVo7B7VT4K71y8h7wYSNVXlL3IHVLuBXEGFJZTm3VUtuCbimnhpvKqqz1edYa990OjM6eBNU_E33-M7jfcuMnmfdhTNQiK7x_UAj-zx5ikjsXNfS9GsDvo6QNbTmtGtFmKpupOvgYA9jHOQTLQ8ZyK-8zloeM5Zxx7nr3dMXHnn-JZsKnmQDZ8slBkFE7GDQYF0Cn7Ir774A7VwK7gA |
CitedBy_id | crossref_primary_10_1016_j_ejmech_2024_116270 crossref_primary_10_1016_j_drudis_2023_103800 crossref_primary_10_1016_j_chembiol_2023_12_005 crossref_primary_10_1016_j_lfs_2024_122782 crossref_primary_10_1016_j_isci_2023_107755 crossref_primary_10_3390_molecules29071575 crossref_primary_10_1016_j_bcp_2023_115989 |
Cites_doi | 10.1002/cam4.2101 10.1021/acs.jmedchem.5b01735 10.1186/s13045-020-00885-3 10.1096/fj.04-2591hyp 10.1016/j.drudis.2020.07.013 10.3389/fphar.2018.01428 10.1016/j.redox.2022.102552 10.1016/j.ddtec.2019.02.005 10.1016/j.cub.2014.03.034 10.1016/j.livres.2019.10.002 10.1016/j.redox.2012.10.001 10.1016/j.bbamcr.2018.02.010 10.1016/j.ejmech.2020.112891 10.1152/physrev.00023.2017 10.1038/s41598-019-56177-5 10.1038/nprot.2006.378 10.1016/j.taap.2009.07.024 10.15585/mmwr.mm7216a3 10.1186/s42826-022-00133-4 10.3390/molecules25225474 10.1016/j.chembiol.2022.08.003 10.1016/j.jsb.2014.10.010 10.1016/j.xpro.2020.100086 10.1016/0006-2952(73)90196-2 10.1016/j.biopha.2022.113514 10.1021/acs.jmedchem.6b00228 10.3390/nu12113585 10.1089/ars.2008.2242 10.1021/acsptsci.2c00165 10.1080/1061186X.2020.1870987 10.1016/j.apsb.2021.09.023 10.14336/AD.2018.0513 10.1016/j.lfs.2021.120111 10.1186/1742-4682-9-55 10.3390/ijms161125942 10.1155/2019/6175804 10.1517/14728220903025762 10.1016/j.ddtec.2019.01.002 10.1016/bs.apha.2019.01.007 10.1038/s41541-022-00453-5 |
ContentType | Journal Article |
Copyright | 2023 The Author(s) Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. 2023 The Author(s) 2023 |
Copyright_xml | – notice: 2023 The Author(s) – notice: Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. – notice: 2023 The Author(s) 2023 |
DBID | 6I. AAFTH NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.1016/j.redox.2023.102783 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2213-2317 |
EndPage | 102783 |
ExternalDocumentID | oai_doaj_org_article_c914f61dd15f42f592f9ec9242d4d5fa 10_1016_j_redox_2023_102783 37348157 S2213231723001842 |
Genre | Journal Article |
GroupedDBID | 0R~ 0SF 457 53G 5VS 6I. AACTN AAEDT AAEDW AAFTH AAIKJ AALRI AAXUO ABGSF ABMAC ACGFS ADBBV ADEZE ADRAZ ADUVX AENEX AEXQZ AFTJW AGHFR AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BCNDV DIK EBS EJD FDB GROUPED_DOAJ HYE HZ~ IPNFZ IXB M48 MO0 M~E NCXOZ O-L O9- OK1 RIG ROL RPM SSZ ADVLN AFJKZ AKRWK NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c526t-d4b26867c94df2d80ad600f57beb8effa1ed7d39ea3c003b3eff10393b1e5d3 |
IEDL.DBID | RPM |
ISSN | 2213-2317 |
IngestDate | Fri Oct 04 13:13:15 EDT 2024 Tue Sep 17 21:30:10 EDT 2024 Fri Aug 16 02:14:07 EDT 2024 Thu Sep 26 19:27:23 EDT 2024 Sat Sep 28 08:18:32 EDT 2024 Sat Aug 05 15:52:41 EDT 2023 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Oxidative stress KEAP1 Proteolysis-targeting chimera (PROTAC) NRF2 Liver |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c526t-d4b26867c94df2d80ad600f57beb8effa1ed7d39ea3c003b3eff10393b1e5d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work. |
ORCID | 0000-0003-3678-2772 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333676/ |
PMID | 37348157 |
PQID | 2829425869 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_c914f61dd15f42f592f9ec9242d4d5fa pubmedcentral_primary_oai_pubmedcentral_nih_gov_10333676 proquest_miscellaneous_2829425869 crossref_primary_10_1016_j_redox_2023_102783 pubmed_primary_37348157 elsevier_sciencedirect_doi_10_1016_j_redox_2023_102783 |
PublicationCentury | 2000 |
PublicationDate | 2023-08-01 |
PublicationDateYYYYMMDD | 2023-08-01 |
PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Redox biology |
PublicationTitleAlternate | Redox Biol |
PublicationYear | 2023 |
Publisher | Elsevier B.V Elsevier |
Publisher_xml | – name: Elsevier B.V – name: Elsevier |
References | Ulasov, Rosenkranz, Georgiev, Sobolev (bib23) 2022; 291 Lee, Cho, Nguyen, Vo, Chae, Maeng (bib42) 2022; 153 Bellezza, Giambanco, Minelli, Donato (bib25) 2018; 1865 Jaeschke, Adelusi, Akakpo, Nguyen, Sanchez-Guerrero, Umbaugh (bib33) 2021; 11 Pike, Williamson, Harlfinger, Martin, McGinnity (bib36) 2020; 25 Hartmann, Boichenko, Coles, Zanini, Lupas, Hernandez Alvarez (bib38) 2014; 188 Farah, Rege, Cole, Holstege (bib27) 2023; 72 Schieber, Chandel (bib3) 2014; 24 Yamamoto, Kensler, Motohashi (bib11) 2018; 98 Charni-Natan, Goldstein (bib40) 2020; 1 Cho, Kleeberger (bib8) 2010; 244 Davies, Wixted, Coyle, Griffiths-Jones, Hearn, McMenamin (bib21) 2016; 59 Kansanen, Kuosmanen, Leinonen, Levonen (bib12) 2013; 1 Snezhkina, Kudryavtseva, Kardymon, Savvateeva, Melnikova, Krasnov (bib1) 2019; 2019 Pisoschi, Pop, Iordache, Stanca, Predoi, Serban (bib2) 2021; 209 Ooi, Dhar, Petruschke, Locht, Buchy, Low (bib26) 2022; 7 Kim, Kang, Jung, Park, Phan, Namgung (bib43) 2020; 12 Du, Jiang, Henning, Safaee, Koide, Nowak (bib18) 2022; 29 Yoon, Babar, Choudhary, Kutner, Pyrsopoulos (bib32) 2016; 4 Jaeschke, Xie, McGill (bib30) 2014; 2 Li, Ichikawa, Janicki, Cui (bib7) 2009; 13 Li, Song (bib16) 2020; 13 Jaeschke, Duan, Nguyen, Ramachandran (bib31) 2019; 3 Boichenko, Deiss, Bar, Hartmann, Hernandez Alvarez (bib37) 2016; 59 Li, Tan, Wang, Zhang, Lao, Wong (bib34) 2015; 16 Chen, Nguyen, Magtoto, Cobbold, Bidgood, Meza Guzman (bib19) 2023; 59 Wu, Lu, Bai (bib5) 2019; 8 Kim, Lee, Park, Jo, Ku, Park (bib24) 2019; 9 Percie du Sert, Ahluwalia, Alam, Avey, Baker, Browne (bib41) 2020; 18 Saha, Buttari, Panieri, Profumo, Saso (bib10) 2020; 25 Cheng, Prusoff (bib39) 1973; 22 Xu, Xu, Jeong, Qian, Wu, Xia (bib4) 2018; 9 Tu, Wang, Li, Liu, Sha (bib15) 2019; 10 Pettersson, Crews (bib17) 2019; 31 Joelsson, Asbjarnarson, Sigurdsson, Kricker, Valdimarsdottir, Thorarinsdottir (bib9) 2022; 38 Qi, Dong (bib14) 2021; 29 Ben-Shachar, Chen, Luo, Hartman, Reed, Nijhout (bib28) 2012; 9 Rahman, Kode, Biswas (bib44) 2006; 1 Lilienbaum (bib22) 2013; 4 Watt, Scott-Stevens, Gaohua (bib35) 2019; 31 Calkins, Johnson, Townsend, Vargas, Dowell, Williamson (bib6) 2009; 11 Lee, Li, Johnson, Stein, Kraft, Calkins (bib13) 2005; 19 Ramachandran, Jaeschke (bib29) 2019; 85 Wang, Zhan, Li, Wang, Zheng, Liu (bib20) 2023; 6 Davies (10.1016/j.redox.2023.102783_bib21) 2016; 59 Ben-Shachar (10.1016/j.redox.2023.102783_bib28) 2012; 9 Kim (10.1016/j.redox.2023.102783_bib43) 2020; 12 Cheng (10.1016/j.redox.2023.102783_bib39) 1973; 22 Li (10.1016/j.redox.2023.102783_bib7) 2009; 13 Yamamoto (10.1016/j.redox.2023.102783_bib11) 2018; 98 Wang (10.1016/j.redox.2023.102783_bib20) 2023; 6 Hartmann (10.1016/j.redox.2023.102783_bib38) 2014; 188 Li (10.1016/j.redox.2023.102783_bib16) 2020; 13 Xu (10.1016/j.redox.2023.102783_bib4) 2018; 9 Cho (10.1016/j.redox.2023.102783_bib8) 2010; 244 Schieber (10.1016/j.redox.2023.102783_bib3) 2014; 24 Bellezza (10.1016/j.redox.2023.102783_bib25) 2018; 1865 Kansanen (10.1016/j.redox.2023.102783_bib12) 2013; 1 Kim (10.1016/j.redox.2023.102783_bib24) 2019; 9 Lilienbaum (10.1016/j.redox.2023.102783_bib22) 2013; 4 Tu (10.1016/j.redox.2023.102783_bib15) 2019; 10 Snezhkina (10.1016/j.redox.2023.102783_bib1) 2019; 2019 Wu (10.1016/j.redox.2023.102783_bib5) 2019; 8 Pettersson (10.1016/j.redox.2023.102783_bib17) 2019; 31 Percie du Sert (10.1016/j.redox.2023.102783_bib41) 2020; 18 Joelsson (10.1016/j.redox.2023.102783_bib9) 2022; 38 Pike (10.1016/j.redox.2023.102783_bib36) 2020; 25 Saha (10.1016/j.redox.2023.102783_bib10) 2020; 25 Watt (10.1016/j.redox.2023.102783_bib35) 2019; 31 Farah (10.1016/j.redox.2023.102783_bib27) 2023; 72 Rahman (10.1016/j.redox.2023.102783_bib44) 2006; 1 Ulasov (10.1016/j.redox.2023.102783_bib23) 2022; 291 Jaeschke (10.1016/j.redox.2023.102783_bib30) 2014; 2 Calkins (10.1016/j.redox.2023.102783_bib6) 2009; 11 Ooi (10.1016/j.redox.2023.102783_bib26) 2022; 7 Pisoschi (10.1016/j.redox.2023.102783_bib2) 2021; 209 Boichenko (10.1016/j.redox.2023.102783_bib37) 2016; 59 Lee (10.1016/j.redox.2023.102783_bib13) 2005; 19 Du (10.1016/j.redox.2023.102783_bib18) 2022; 29 Chen (10.1016/j.redox.2023.102783_bib19) 2023; 59 Jaeschke (10.1016/j.redox.2023.102783_bib33) 2021; 11 Li (10.1016/j.redox.2023.102783_bib34) 2015; 16 Lee (10.1016/j.redox.2023.102783_bib42) 2022; 153 Charni-Natan (10.1016/j.redox.2023.102783_bib40) 2020; 1 Qi (10.1016/j.redox.2023.102783_bib14) 2021; 29 Yoon (10.1016/j.redox.2023.102783_bib32) 2016; 4 Jaeschke (10.1016/j.redox.2023.102783_bib31) 2019; 3 Ramachandran (10.1016/j.redox.2023.102783_bib29) 2019; 85 |
References_xml | – volume: 19 start-page: 1061 year: 2005 end-page: 1066 ident: bib13 article-title: Nrf2, a multi-organ protector? publication-title: Faseb. J. contributor: fullname: Calkins – volume: 6 start-page: 76 year: 2023 end-page: 87 ident: bib20 article-title: Cell-permeable PROTAC degraders against KEAP1 efficiently suppress hepatic stellate cell activation through the antioxidant and anti-inflammatory pathway publication-title: ACS Pharmacol Transl Sci contributor: fullname: Liu – volume: 24 start-page: R453 year: 2014 end-page: R462 ident: bib3 article-title: ROS function in redox signaling and oxidative stress publication-title: Curr. Biol. contributor: fullname: Chandel – volume: 29 start-page: 1470 year: 2022 end-page: 1481 e31 ident: bib18 article-title: Exploring the target scope of KEAP1 E3 ligase-based PROTACs publication-title: Cell Chem. Biol. contributor: fullname: Nowak – volume: 11 start-page: 497 year: 2009 end-page: 508 ident: bib6 article-title: The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease publication-title: Antioxidants Redox Signal. contributor: fullname: Williamson – volume: 1 year: 2020 ident: bib40 article-title: Protocol for primary mouse hepatocyte isolation publication-title: STAR Protoc contributor: fullname: Goldstein – volume: 291 year: 2022 ident: bib23 article-title: Nrf2/Keap1/ARE signaling: towards specific regulation publication-title: Life Sci. contributor: fullname: Sobolev – volume: 38 start-page: 23 year: 2022 ident: bib9 article-title: Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model publication-title: Lab Anim Res contributor: fullname: Thorarinsdottir – volume: 7 start-page: 31 year: 2022 ident: bib26 article-title: Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination publication-title: NPJ Vaccines contributor: fullname: Low – volume: 16 start-page: 26087 year: 2015 end-page: 26124 ident: bib34 article-title: The role of oxidative stress and antioxidants in liver diseases publication-title: Int. J. Mol. Sci. contributor: fullname: Wong – volume: 4 start-page: 131 year: 2016 end-page: 142 ident: bib32 article-title: Acetaminophen-induced hepatotoxicity: a comprehensive update publication-title: J Clin Transl Hepatol contributor: fullname: Pyrsopoulos – volume: 209 year: 2021 ident: bib2 article-title: Oxidative stress mitigation by antioxidants - an overview on their chemistry and influences on health status publication-title: Eur. J. Med. Chem. contributor: fullname: Serban – volume: 153 year: 2022 ident: bib42 article-title: Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: potential of its pharmacokinetic interactions in vivo publication-title: Biomed. Pharmacother. contributor: fullname: Maeng – volume: 1 start-page: 3159 year: 2006 end-page: 3165 ident: bib44 article-title: Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method publication-title: Nat. Protoc. contributor: fullname: Biswas – volume: 1 start-page: 45 year: 2013 end-page: 49 ident: bib12 article-title: The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer publication-title: Redox Biol. contributor: fullname: Levonen – volume: 31 start-page: 15 year: 2019 end-page: 27 ident: bib17 article-title: PROteolysis TArgeting Chimeras (PROTACs) - past, present and future publication-title: Drug Discov. Today Technol. contributor: fullname: Crews – volume: 4 start-page: 1 year: 2013 end-page: 26 ident: bib22 article-title: Relationship between the proteasomal system and autophagy publication-title: Int J Biochem Mol Biol contributor: fullname: Lilienbaum – volume: 31 start-page: 69 year: 2019 end-page: 80 ident: bib35 article-title: Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: current status and future considerations publication-title: Drug Discov. Today Technol. contributor: fullname: Gaohua – volume: 59 start-page: 770 year: 2016 end-page: 774 ident: bib37 article-title: A FRET-based assay for the identification and characterization of cereblon ligands publication-title: J. Med. Chem. contributor: fullname: Hernandez Alvarez – volume: 244 start-page: 43 year: 2010 end-page: 56 ident: bib8 article-title: Nrf2 protects against airway disorders publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Kleeberger – volume: 9 year: 2019 ident: bib24 article-title: Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera publication-title: Sci. Rep. contributor: fullname: Park – volume: 25 start-page: 1793 year: 2020 end-page: 1800 ident: bib36 article-title: Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective publication-title: Drug Discov. Today contributor: fullname: McGinnity – volume: 98 start-page: 1169 year: 2018 end-page: 1203 ident: bib11 article-title: The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis publication-title: Physiol. Rev. contributor: fullname: Motohashi – volume: 13 start-page: 50 year: 2020 ident: bib16 article-title: Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy publication-title: J. Hematol. Oncol. contributor: fullname: Song – volume: 9 start-page: 1428 year: 2018 ident: bib4 article-title: The role of Nrf2 in liver disease: novel molecular mechanisms and therapeutic approaches publication-title: Front. Pharmacol. contributor: fullname: Xia – volume: 25 year: 2020 ident: bib10 article-title: An overview of Nrf2 signaling pathway and its role in inflammation publication-title: Molecules contributor: fullname: Saso – volume: 29 start-page: 677 year: 2021 end-page: 686 ident: bib14 article-title: The relevant targets of anti-oxidative stress: a review publication-title: J. Drug Target. contributor: fullname: Dong – volume: 2019 year: 2019 ident: bib1 article-title: ROS generation and antioxidant defense systems in normal and malignant cells publication-title: Oxid. Med. Cell. Longev. contributor: fullname: Krasnov – volume: 59 year: 2023 ident: bib19 article-title: Design and characterization of a heterobifunctional degrader of KEAP1 publication-title: Redox Biol. contributor: fullname: Meza Guzman – volume: 59 start-page: 3991 year: 2016 end-page: 4006 ident: bib21 article-title: Monoacidic inhibitors of the Kelch-like ECH-associated protein 1: nuclear factor erythroid 2-related factor 2 (KEAP1:NRF2) protein-protein interaction with high cell potency identified by fragment-based Discovery publication-title: J. Med. Chem. contributor: fullname: McMenamin – volume: 3 start-page: 150 year: 2019 end-page: 156 ident: bib31 article-title: Mitochondrial damage and biogenesis in acetaminophen-induced liver injury publication-title: Liver Res contributor: fullname: Ramachandran – volume: 72 start-page: 426 year: 2023 end-page: 430 ident: bib27 article-title: Suspected suicide attempts by self-poisoning among persons aged 10-19 Years during the COVID-19 pandemic - United States, 2020-2022 publication-title: MMWR Morb. Mortal. Wkly. Rep. contributor: fullname: Holstege – volume: 11 start-page: 3740 year: 2021 end-page: 3755 ident: bib33 article-title: Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls publication-title: Acta Pharm. Sin. B contributor: fullname: Umbaugh – volume: 22 start-page: 3099 year: 1973 end-page: 3108 ident: bib39 article-title: Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction publication-title: Biochem. Pharmacol. contributor: fullname: Prusoff – volume: 10 start-page: 637 year: 2019 end-page: 651 ident: bib15 article-title: The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases publication-title: Aging Dis contributor: fullname: Sha – volume: 188 start-page: 225 year: 2014 end-page: 232 ident: bib38 article-title: Thalidomide mimics uridine binding to an aromatic cage in cereblon publication-title: J. Struct. Biol. contributor: fullname: Hernandez Alvarez – volume: 2 start-page: 153 year: 2014 end-page: 161 ident: bib30 article-title: Acetaminophen-induced liver injury: from animal models to humans publication-title: J Clin Transl Hepatol contributor: fullname: McGill – volume: 1865 start-page: 721 year: 2018 end-page: 733 ident: bib25 article-title: Nrf2-Keap1 signaling in oxidative and reductive stress publication-title: Biochim. Biophys. Acta Mol. Cell Res. contributor: fullname: Donato – volume: 85 start-page: 195 year: 2019 end-page: 219 ident: bib29 article-title: Acetaminophen hepatotoxicity: a mitochondrial perspective publication-title: Adv. Pharmacol. contributor: fullname: Jaeschke – volume: 8 start-page: 2252 year: 2019 end-page: 2267 ident: bib5 article-title: Nrf2 in cancers: a double-edged sword publication-title: Cancer Med. contributor: fullname: Bai – volume: 13 start-page: 785 year: 2009 end-page: 794 ident: bib7 article-title: Targeting the Nrf2 pathway against cardiovascular disease publication-title: Expert Opin. Ther. Targets contributor: fullname: Cui – volume: 12 year: 2020 ident: bib43 article-title: Allyl isothiocyanate protects acetaminophen-induced liver injury via NRF2 activation by decreasing spontaneous degradation in hepatocyte publication-title: Nutrients contributor: fullname: Namgung – volume: 9 start-page: 55 year: 2012 ident: bib28 article-title: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model publication-title: Theor. Biol. Med. Model. contributor: fullname: Nijhout – volume: 18 year: 2020 ident: bib41 article-title: Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0 publication-title: PLoS Biol. contributor: fullname: Browne – volume: 8 start-page: 2252 issue: 5 year: 2019 ident: 10.1016/j.redox.2023.102783_bib5 article-title: Nrf2 in cancers: a double-edged sword publication-title: Cancer Med. doi: 10.1002/cam4.2101 contributor: fullname: Wu – volume: 59 start-page: 770 issue: 2 year: 2016 ident: 10.1016/j.redox.2023.102783_bib37 article-title: A FRET-based assay for the identification and characterization of cereblon ligands publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.5b01735 contributor: fullname: Boichenko – volume: 13 start-page: 50 issue: 1 year: 2020 ident: 10.1016/j.redox.2023.102783_bib16 article-title: Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-020-00885-3 contributor: fullname: Li – volume: 19 start-page: 1061 issue: 9 year: 2005 ident: 10.1016/j.redox.2023.102783_bib13 article-title: Nrf2, a multi-organ protector? publication-title: Faseb. J. doi: 10.1096/fj.04-2591hyp contributor: fullname: Lee – volume: 25 start-page: 1793 issue: 10 year: 2020 ident: 10.1016/j.redox.2023.102783_bib36 article-title: Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2020.07.013 contributor: fullname: Pike – volume: 9 start-page: 1428 year: 2018 ident: 10.1016/j.redox.2023.102783_bib4 article-title: The role of Nrf2 in liver disease: novel molecular mechanisms and therapeutic approaches publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.01428 contributor: fullname: Xu – volume: 59 year: 2023 ident: 10.1016/j.redox.2023.102783_bib19 article-title: Design and characterization of a heterobifunctional degrader of KEAP1 publication-title: Redox Biol. doi: 10.1016/j.redox.2022.102552 contributor: fullname: Chen – volume: 31 start-page: 69 year: 2019 ident: 10.1016/j.redox.2023.102783_bib35 article-title: Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: current status and future considerations publication-title: Drug Discov. Today Technol. doi: 10.1016/j.ddtec.2019.02.005 contributor: fullname: Watt – volume: 24 start-page: R453 issue: 10 year: 2014 ident: 10.1016/j.redox.2023.102783_bib3 article-title: ROS function in redox signaling and oxidative stress publication-title: Curr. Biol. doi: 10.1016/j.cub.2014.03.034 contributor: fullname: Schieber – volume: 3 start-page: 150 issue: 3–4 year: 2019 ident: 10.1016/j.redox.2023.102783_bib31 article-title: Mitochondrial damage and biogenesis in acetaminophen-induced liver injury publication-title: Liver Res doi: 10.1016/j.livres.2019.10.002 contributor: fullname: Jaeschke – volume: 1 start-page: 45 issue: 1 year: 2013 ident: 10.1016/j.redox.2023.102783_bib12 article-title: The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer publication-title: Redox Biol. doi: 10.1016/j.redox.2012.10.001 contributor: fullname: Kansanen – volume: 1865 start-page: 721 issue: 5 year: 2018 ident: 10.1016/j.redox.2023.102783_bib25 article-title: Nrf2-Keap1 signaling in oxidative and reductive stress publication-title: Biochim. Biophys. Acta Mol. Cell Res. doi: 10.1016/j.bbamcr.2018.02.010 contributor: fullname: Bellezza – volume: 209 year: 2021 ident: 10.1016/j.redox.2023.102783_bib2 article-title: Oxidative stress mitigation by antioxidants - an overview on their chemistry and influences on health status publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2020.112891 contributor: fullname: Pisoschi – volume: 98 start-page: 1169 issue: 3 year: 2018 ident: 10.1016/j.redox.2023.102783_bib11 article-title: The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis publication-title: Physiol. Rev. doi: 10.1152/physrev.00023.2017 contributor: fullname: Yamamoto – volume: 9 issue: 1 year: 2019 ident: 10.1016/j.redox.2023.102783_bib24 article-title: Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera publication-title: Sci. Rep. doi: 10.1038/s41598-019-56177-5 contributor: fullname: Kim – volume: 1 start-page: 3159 issue: 6 year: 2006 ident: 10.1016/j.redox.2023.102783_bib44 article-title: Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.378 contributor: fullname: Rahman – volume: 244 start-page: 43 issue: 1 year: 2010 ident: 10.1016/j.redox.2023.102783_bib8 article-title: Nrf2 protects against airway disorders publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2009.07.024 contributor: fullname: Cho – volume: 72 start-page: 426 issue: 16 year: 2023 ident: 10.1016/j.redox.2023.102783_bib27 article-title: Suspected suicide attempts by self-poisoning among persons aged 10-19 Years during the COVID-19 pandemic - United States, 2020-2022 publication-title: MMWR Morb. Mortal. Wkly. Rep. doi: 10.15585/mmwr.mm7216a3 contributor: fullname: Farah – volume: 18 issue: 7 year: 2020 ident: 10.1016/j.redox.2023.102783_bib41 article-title: Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0 publication-title: PLoS Biol. contributor: fullname: Percie du Sert – volume: 38 start-page: 23 issue: 1 year: 2022 ident: 10.1016/j.redox.2023.102783_bib9 article-title: Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model publication-title: Lab Anim Res doi: 10.1186/s42826-022-00133-4 contributor: fullname: Joelsson – volume: 25 issue: 22 year: 2020 ident: 10.1016/j.redox.2023.102783_bib10 article-title: An overview of Nrf2 signaling pathway and its role in inflammation publication-title: Molecules doi: 10.3390/molecules25225474 contributor: fullname: Saha – volume: 29 start-page: 1470 issue: 10 year: 2022 ident: 10.1016/j.redox.2023.102783_bib18 article-title: Exploring the target scope of KEAP1 E3 ligase-based PROTACs publication-title: Cell Chem. Biol. doi: 10.1016/j.chembiol.2022.08.003 contributor: fullname: Du – volume: 2 start-page: 153 issue: 3 year: 2014 ident: 10.1016/j.redox.2023.102783_bib30 article-title: Acetaminophen-induced liver injury: from animal models to humans publication-title: J Clin Transl Hepatol contributor: fullname: Jaeschke – volume: 188 start-page: 225 issue: 3 year: 2014 ident: 10.1016/j.redox.2023.102783_bib38 article-title: Thalidomide mimics uridine binding to an aromatic cage in cereblon publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2014.10.010 contributor: fullname: Hartmann – volume: 1 issue: 2 year: 2020 ident: 10.1016/j.redox.2023.102783_bib40 article-title: Protocol for primary mouse hepatocyte isolation publication-title: STAR Protoc doi: 10.1016/j.xpro.2020.100086 contributor: fullname: Charni-Natan – volume: 22 start-page: 3099 issue: 23 year: 1973 ident: 10.1016/j.redox.2023.102783_bib39 article-title: Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(73)90196-2 contributor: fullname: Cheng – volume: 4 start-page: 131 issue: 2 year: 2016 ident: 10.1016/j.redox.2023.102783_bib32 article-title: Acetaminophen-induced hepatotoxicity: a comprehensive update publication-title: J Clin Transl Hepatol contributor: fullname: Yoon – volume: 153 year: 2022 ident: 10.1016/j.redox.2023.102783_bib42 article-title: Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: potential of its pharmacokinetic interactions in vivo publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2022.113514 contributor: fullname: Lee – volume: 59 start-page: 3991 issue: 8 year: 2016 ident: 10.1016/j.redox.2023.102783_bib21 article-title: Monoacidic inhibitors of the Kelch-like ECH-associated protein 1: nuclear factor erythroid 2-related factor 2 (KEAP1:NRF2) protein-protein interaction with high cell potency identified by fragment-based Discovery publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.6b00228 contributor: fullname: Davies – volume: 12 issue: 11 year: 2020 ident: 10.1016/j.redox.2023.102783_bib43 article-title: Allyl isothiocyanate protects acetaminophen-induced liver injury via NRF2 activation by decreasing spontaneous degradation in hepatocyte publication-title: Nutrients doi: 10.3390/nu12113585 contributor: fullname: Kim – volume: 11 start-page: 497 issue: 3 year: 2009 ident: 10.1016/j.redox.2023.102783_bib6 article-title: The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease publication-title: Antioxidants Redox Signal. doi: 10.1089/ars.2008.2242 contributor: fullname: Calkins – volume: 6 start-page: 76 issue: 1 year: 2023 ident: 10.1016/j.redox.2023.102783_bib20 article-title: Cell-permeable PROTAC degraders against KEAP1 efficiently suppress hepatic stellate cell activation through the antioxidant and anti-inflammatory pathway publication-title: ACS Pharmacol Transl Sci doi: 10.1021/acsptsci.2c00165 contributor: fullname: Wang – volume: 29 start-page: 677 issue: 7 year: 2021 ident: 10.1016/j.redox.2023.102783_bib14 article-title: The relevant targets of anti-oxidative stress: a review publication-title: J. Drug Target. doi: 10.1080/1061186X.2020.1870987 contributor: fullname: Qi – volume: 4 start-page: 1 issue: 1 year: 2013 ident: 10.1016/j.redox.2023.102783_bib22 article-title: Relationship between the proteasomal system and autophagy publication-title: Int J Biochem Mol Biol contributor: fullname: Lilienbaum – volume: 11 start-page: 3740 issue: 12 year: 2021 ident: 10.1016/j.redox.2023.102783_bib33 article-title: Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2021.09.023 contributor: fullname: Jaeschke – volume: 10 start-page: 637 issue: 3 year: 2019 ident: 10.1016/j.redox.2023.102783_bib15 article-title: The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases publication-title: Aging Dis doi: 10.14336/AD.2018.0513 contributor: fullname: Tu – volume: 291 year: 2022 ident: 10.1016/j.redox.2023.102783_bib23 article-title: Nrf2/Keap1/ARE signaling: towards specific regulation publication-title: Life Sci. doi: 10.1016/j.lfs.2021.120111 contributor: fullname: Ulasov – volume: 9 start-page: 55 year: 2012 ident: 10.1016/j.redox.2023.102783_bib28 article-title: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model publication-title: Theor. Biol. Med. Model. doi: 10.1186/1742-4682-9-55 contributor: fullname: Ben-Shachar – volume: 16 start-page: 26087 issue: 11 year: 2015 ident: 10.1016/j.redox.2023.102783_bib34 article-title: The role of oxidative stress and antioxidants in liver diseases publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms161125942 contributor: fullname: Li – volume: 2019 year: 2019 ident: 10.1016/j.redox.2023.102783_bib1 article-title: ROS generation and antioxidant defense systems in normal and malignant cells publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2019/6175804 contributor: fullname: Snezhkina – volume: 13 start-page: 785 issue: 7 year: 2009 ident: 10.1016/j.redox.2023.102783_bib7 article-title: Targeting the Nrf2 pathway against cardiovascular disease publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728220903025762 contributor: fullname: Li – volume: 31 start-page: 15 year: 2019 ident: 10.1016/j.redox.2023.102783_bib17 article-title: PROteolysis TArgeting Chimeras (PROTACs) - past, present and future publication-title: Drug Discov. Today Technol. doi: 10.1016/j.ddtec.2019.01.002 contributor: fullname: Pettersson – volume: 85 start-page: 195 year: 2019 ident: 10.1016/j.redox.2023.102783_bib29 article-title: Acetaminophen hepatotoxicity: a mitochondrial perspective publication-title: Adv. Pharmacol. doi: 10.1016/bs.apha.2019.01.007 contributor: fullname: Ramachandran – volume: 7 start-page: 31 issue: 1 year: 2022 ident: 10.1016/j.redox.2023.102783_bib26 article-title: Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination publication-title: NPJ Vaccines doi: 10.1038/s41541-022-00453-5 contributor: fullname: Ooi |
SSID | ssj0000884210 |
Score | 2.4215755 |
Snippet | Oxidative stress due to abnormal accumulation of reactive oxygen species (ROS) is an initiator of a large number of human diseases, and thus, the elimination... |
SourceID | doaj pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 102783 |
SubjectTerms | KEAP1 Liver NRF2 Oxidative stress Proteolysis-targeting chimera (PROTAC) Research Paper |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3bS90wGA9DEPYim07XzUkGe1z15Namvh1FcRub4gXEl5Ardg-tHKvof798zamcOnAveypNQ9rvkuSX5OvvQ-gLY4QYGkQe4PdfHmSVa2ptXjqrHZWaSgNbAz9_FUcX_PuluFxI9QUxYYkeOClux1aEh4I4R0TgsdGKhsrbuGqgjjsREjQiYmEx1Y_BUnLaUxFQSlgeQUw5UA71wV1AxvmwDanDgbuglGw0LfXs_aPZ6W_0-TyIcmFWOnyDVuZwEk-TGG_RK9-souWUYPJxDV0txAThNuAfB9MTkqfo7zhn4ZPT4_PpPtaNw3V3G6_RTA-1i1d8A7v0M6Bb3cXfGnxfd7M2VYSb-_YdOjs8ON8_yufZFHIraNHljhtayKK0FXeBOjnRLoKdIErjjfQhaOJd6VjlNbOxqxsWy-CcmBnihWPraKlpG_8eYc0ZLybcygl3XApgFAzSAC-Yll4KmqGvgyrVTaLMUEMs2W_Va16B5lXSfIb2QN1PVYHvui-IXqDmXqD-5QUZKgZjqTl0SJAgNlW__PbPg2lV7FhwWqIb397dKjhijgOaLKoMbSRTP30jA04gIsoMyZETjIQYP2nq6568O6qUAUveh_8h9kf0GmRJAYmbaKmb3flPESR1ZqvvD38A1AMOgA priority: 102 providerName: Directory of Open Access Journals – databaseName: ScienceDirect dbid: IXB link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqSkhcEFAeAVoZiSNhN34kDrftqlUBARUt0oqLZcd2CYdktU2r8u87EyerBiQOnCw7TuzMeB62x58JecN5llkWZBrw-K8IqkwNq6q0cJVxTBmmLC4NfP6Sn3wXH1dytUOW41kYDKscdH_U6b22HkpmAzVn67qenTEGMykwf-BEz2GegnoYsT3xEN_qcLvOAlIkWA9KgPVTfGEEH-rDvBCW8-YdXiKOKAaF4hMD1eP4T-zU337on-GUd-zT8UPyYHAs6SL2_RHZ8c1jci9eNfl7j_y4Ex1E20A_HS1OszTGgYP1oqffvp4vltQ0jtbdJaTAsJvaQUrXuF6_QeDV9_RDQ6_rbtPGipi5bp-Qs-Oj8-VJOtyrkFaS5V3qhGW5youqFC4wp-bGgdsTZGG9VT4Ek3lXOF56wysQesuhDHeMuc28dPwp2W3axj8n1Agu8rmo1Fw4oSRiCwZlESHMKK8kS8jbkZR6HcEz9BhV9kv3lNdIeR0pn5BDJPe2KiJf9wXt5kIPrNdVmYmQZ85lMggYZCULpa9gFsmccDKYhOQjs_RkIMGn6n-3_npkrQYRw30T0_j26lLjZjOoNpWXCXkWWb3tI0d0oEwWCVGTQTD5iemTpv7Zw3gDSTni5b343x6_JPcxF8MRX5HdbnPl98FF6uxBLwO32SsOlw priority: 102 providerName: Elsevier – databaseName: Scholars Portal Journals: Open Access(OpenAccess) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ba9YwFA9zIvgyvFudEsFHO77c2lSQ8Tk2pjIdusHwJaS5uI7Rzn7d-Pbfm9O0c9Xhg08haUjTc8k5SU5_B6HXjBFSUi9SD7__ci-LVFNj0twabanUVJZwNLD3Ods95B-PxNEKGrOiDgRc3Li1g3xSh-3pxvLn5WZQ-He_Y7UAW3O5AZnAAYogl-wWuk054yDye4O_3y_NUnLaIxRQSlgafJt8RCK6eZyJtepB_SdG62-n9M_YymvGauceWhu8TDyPYnEfrbj6AboT805ePkTfr4UK4cbjT9vzfZLGoPBgyvD-1y8H8y2sa4urbhHKwL1lZUOJz-DwvgUU1rf4Q40vqq5tYkeoXDSP0Led7YOt3XRIspAaQbMutbykmcxyU3DrqZUzbYMP5EVeulI67zVxNrescJqZsAKULLTB9TEriROWPUardVO7pwhroPeMGznjlksBQINelgAXpqWTgibozUhKdRaRNNQYYnaiesoroLyKlE_QeyD3VVeAwe4bmvaHGrRKmYJwnxFrifA8SFxBfeFM2FJSy63wOkHZyCw1eBTRUwhDVf9--6uRtSroG1yi6No15wsFN89hnZNZkaAnkdVXc2QAFUREniA5EYLJR0yf1NVxj-kdSMoAPO_Z_874OboLtRibuI5Wu_bcvQj-Ule-7HXgF5AIEt8 priority: 102 providerName: Scholars Portal |
Title | Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo |
URI | https://dx.doi.org/10.1016/j.redox.2023.102783 https://www.ncbi.nlm.nih.gov/pubmed/37348157 https://search.proquest.com/docview/2829425869 https://pubmed.ncbi.nlm.nih.gov/PMC10333676 https://doaj.org/article/c914f61dd15f42f592f9ec9242d4d5fa |
Volume | 64 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa2SUi8oG3cwmAyEo-krS9JHN66atMGKlQwpIoXy9cRxJKqy6bt3-PjNFPLJB54iRXHSWyfY59j-_NnhN4xRoimPks9bP_lXpSposakhTXKUqGo0DA1MP2cn37nH-fZfAvl_V6YCNo3uhrUvy8HdfUzYisXl2bY48SGs-mEjBgDprHhNtouGFsbo8f-VwgeBjI9xVAEcwH55u0AjgoHroJCwPE5DIhdCNilNYsUifs3DNNDx_Nv_OSaQTrZRU9WniQedzneQ1uu3kePurMl756iH2twINx4_Ol4PCNpB_wO5grPvn45H0-wqi2u2qsQBgndVjaEeAET9EtgWv2Az2p8U7XLpksINzfNM_Tt5Ph8cpquDlJITUbzNrVc01zkhSm59dSKkbLBz_FZoZ0WzntFnC0sK51iJrRyzUIcLBEzTVxm2XO0Uze1e4mw4oznI27EiFsuMiAT9EIDJZgSTmQ0Qe_7qpSLji1D9jCyXzIKQYIQZCeEBB1Bdd8nBarrGNEsL-RK4NKUhPucWEsyz4NWldSXzoRhI7XcZl4lKO-FJVdeQ-cNhE9V__772160MrQpWChRtWuurySsLoe-TORlgl50or7PY681CRIbSrBRiM0nQY0jb3evtq_-_9UD9BhK0CEQX6Oddnnt3gSvqNWHcTYhXM_mR-E65eIwNos_o2wPyw |
link.rule.ids | 230,315,733,786,790,870,891,2115,3525,24346,27957,27958,45909,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIgQXxJuUl5E4EjbxI3G4bVetdumDii7SiovlxDakh2S1Tavy75nJY9WAxIGTFT8SZ2Y8M7bHnwl5z3kc58zL0OPxX-FVFhpWFGFqC2OZMkzluDRwcprMv4nPK7naIbPhLAyGVfa6v9PprbbucyY9NSfrspycMwYzKTB_4ERHME8BPXxHyCxC0V6s9rcLLTCMBGtRCbBBiC0G9KE2zgtxOW8-4i3iCGOQKj6yUC2Q_8hQ_e2I_hlPectAHT4kD3rPkk67zj8iO656TO52d03-ekK-3woPorWnRwfTszjsAsHBfNGzr1-W0xk1laVlcwkpcOymtJDSNS7YbxB59RNdVPS6bDZ1VxEfruun5PzwYDmbh_3FCmEhWdKEVuQsUUlaZMJ6ZlVkLPg9Xqa5y5Xz3sTOppZnzvACRn3OIQ-3jHkeO2n5M7Jb1ZV7QagRXCSRKFQkrFASwQW9yhEizCinJAvIh4GUet2hZ-ghrOxCt5TXSHndUT4g-0jubVWEvm4z6s0P3fNeF1ksfBJbG0svQMoy5jNXwDSSWWGlNwFJBmbpkSTBq8p_f_3dwFoNYww3Tkzl6qtLjbvNoNtUkgXkecfqbR85wgPFMg2IGgnB6CfGJVX5s8XxBpJyBMzb-98evyX35suTY328OD16Se5jSReb-IrsNpsr9xr8pSZ_046H34mFEb4 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLagCMSFfQmrkTiSmfGSxOE2DB21lJYRFKmCg-UVAjQZzWSqwq_HL0s1UyQOPVlJnOXlffZ7jr98RuglY4Ro6pPYw--_3Is8VtSYOLNGWSoUFRo-DewfpDuf-buj5KhjVS47WmVpdDEofx0PyuJ7w62cH5thzxMbzvYnZMQYKI0N59YPL6MrodHSfG2k3vTCQvAwnOmFhhpKF0hwng5gwXBQLMgELKLDQN6FQHRai0uNfP9GePo3_TzPolwLS9Ob6GtvUMtG-TlY1Xpg_pzTeryYxbfQjS5bxeO2zm10yZV30NV2_crfd9GXNcoRrjze2x7PSNySy0NIxLOPHw7HE6xKi4t6GcqAgtPChhLPYRJgAWqur_FuiU-KelG1FWHjpLqHPk23Dyc7cbdYQ2wSmtax5ZqmIs1Mzq2nVoyUDbmUTzLttHDeK-JsZlnuFDOhJ9Es7INpaKaJSyy7j7bKqnQPEVac8XTEjRhxy0UCgoVeaJAdU8KJhEboVe8oOW8VOWRPVfshGxdLcLFsXRyhN-DMs6ogp93sqBbfZPeKpckJ9ymxliSeB-Tm1OfOhKEptdwmXkUo7aEgu8ykzTjCpYr_3_1FDxwZ2i1MxqjSVaulhBns0F-KNI_QgxZIZ8_YYzJCYgNiG0ZsHgnAabTBe6A8uvipz9G12dupfL97sPcYXQdjWsLjE7RVL1buaUjCav2saW1_AZEpMZ4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+KEAP1-targeting+PROTAC+and+its+antioxidant+properties%3A+In+vitro+and+in+vivo&rft.jtitle=Redox+biology&rft.au=Park%2C+Se+Yong&rft.au=Gurung%2C+Raju&rft.au=Hwang%2C+Jung+Ho&rft.au=Kang%2C+Ju-Hee&rft.date=2023-08-01&rft.pub=Elsevier+B.V&rft.issn=2213-2317&rft.eissn=2213-2317&rft.volume=64&rft_id=info:doi/10.1016%2Fj.redox.2023.102783&rft.externalDocID=S2213231723001842 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2213-2317&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2213-2317&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2213-2317&client=summon |