Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

• Published in: PloS one Vol. 17; no. 2; p. e0263587
• Main Authors: Qin, Guanghao, He, Fang, Zhang, Hongda, Pazo, Emmanuel Eric, Dai, Guangzheng, Yao, Qingchi, He, Wei, Xu, Ling, Lin, Tiezhu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.02.2022; Public Library of Science (PLoS)
• Subjects: Aged; Alzheimer's disease; Atherosclerosis; Biology and Life Sciences; Biomarkers; Blood; Blood Platelets - cytology; Cardiovascular disease; Cataracts; Diabetes; Diabetic retinopathy; Edema; Female; High density lipoprotein; Hospitals; Humans; Hypertension; Inflammation; Ischemia; Leukocytes (neutrophilic); Lymphocyte Count; Lymphocytes; Lymphocytes - cytology; Male; Medicine and Health Sciences; Monocytes; Neutrophils; Neutrophils - cytology; Occlusion; Peripheral blood; Platelet Count; Platelets; Retina; Retinal Artery Occlusion - blood; Retinal Artery Occlusion - physiopathology; Retinal Vein Occlusion; Retrospective Studies; ROC Curve; Sensitivity; Sensitivity and Specificity; Stroke; Treatment Outcome; Vein & artery diseases; Veins; Liaoning China; United States > US; China
• DOI: 10.1371/journal.pone.0263587
• ISSN: 1932-6203

To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). This retrospective study assessed 41 RAO, 50 RVO and 50 control (age and gender matched senile cataract) participants. The NLR, PLR and MHR parameters of patients' peripheral blood were analyzed. A receiver operating characteristics (ROC) curve analysis and the best cutoff value were used to specify the predictive value of NLR, PLR and MHR in RAO and RVO. The NLR, PLR and MHR were significantly higher in RAO group compared to the control group (p<0.001, p<0.001 and p = 0.008; respectively). The NLR, PLR and MHR were also significantly higher in the RVO group compared to the control group (p<0.001, p = 0.001 and p = 0.012, respectively). The NLR and PLR were significantly higher in the RAO group compared to the RVO group (p<0.001 and p = 0.022, respectively). The optimal cut-off value of NLR to predict RAO was >2.99, with 90.2% sensitivity and 100% specificity. The PLR to predict RAO was > 145.52, with 75.6% sensitivity and 80.0% specificity. Higher NLR, PLR and MHR are related to the occurrence of RAO and RVO. NLR and PLR are more prominent in RAO compared to RVO.