Adaptive dating and fast proposals: Revisiting the phylogenetic relaxed clock model

• Published in: PLoS computational biology Vol. 17; no. 2; p. e1008322
• Main Authors: Douglas, Jordan, Zhang, Rong, Bouckaert, Remco
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2021; Public Library of Science (PLoS)
• Subjects: Approximation; Biology and Life Sciences; Clocks & watches; Computer and Information Sciences; Correlation; COVID-19; Expected values; Nucleic acids; Operators; Parameterization; Phylogenetics; Phylogeny; Physical Sciences; Proposals; Real numbers; Research and Analysis Methods; Substitutes

Relaxed clock models enable estimation of molecular substitution rates across lineages and are widely used in phylogenetics for dating evolutionary divergence times. Under the (uncorrelated) relaxed clock model, tree branches are associated with molecular substitution rates which are independently a...