Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 79; no. 4; pp. 184 - 196
• Main Authors: Angrish, Michelle M., Pleil, Joachim D., Stiegel, Matthew A., Madden, Michael C., Moser, Virginia C., Herr, David W.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.02.2016; Taylor & Francis Ltd
• Subjects: Air Pollutants - toxicity; Animals; Biomarkers - blood; Biomarkers - metabolism; Biomarkers - urine; Carbaryl - toxicity; Cytokines; Cytokines - blood; Cytokines - immunology; Cytokines - metabolism; Cytokines - urine; Environmental health; Exposure; Female; High-Throughput Screening Assays - instrumentation; High-Throughput Screening Assays - methods; Human behavior; Humans; Insecticides - toxicity; Male; Markers; Mice; Multiplexing; Ozone - toxicity; Pathways; Pyrazoles - toxicity; Rodents; Statistical methods; Taxonomy; Toxicity Tests - instrumentation; Toxicity Tests - methods; Vehicle Emissions - toxicity

Cytokines, low-molecular-weight messenger proteins that act as intercellular immunomodulatory signals, have become a mainstream preclinical marker for assessing the systemic inflammatory response to external stressors. The challenge is to quantitate from healthy subjects cytokine levels that are bel...