Association between antihypertensive medication use and kidney cancer risk: a meta-analysis accounting for hypertension

• Published in: BMC cancer Vol. 25; no. 1; pp. 1013 - 12
• Main Authors: Jung, Minji, Li, Mingyi, Shin, Jaekyu, Chung, Benjamin I., Langston, Marvin E.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.06.2025; BioMed Central; BMC
• Subjects: Adverse and side effects; Adverse drug reaction; Angiotensin; Angiotensin Receptor Antagonists - adverse effects; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - adverse effects; Antihypertensive Agents - therapeutic use; Antihypertensive drugs; Antihypertensives; Blood pressure; Body mass index; Cohort analysis; Complications and side effects; Diuretics; Dosage and administration; Drugs; Estimates; Humans; Hypertension; Hypertension - complications; Hypertension - drug therapy; Hypoxia; Kidney cancer; Kidney Neoplasms - chemically induced; Kidney Neoplasms - epidemiology; Medical records; Meta-analysis; Observational studies; Observational Studies as Topic; Peptidyl-dipeptidase A; Prevention; Renal cell carcinoma; Risk Factors; United States; Middle East; Canada; Australia; United States > US; Asia; Europe; Hypertension; Antihypertensive drugs; Adverse drug reaction; Renal cell carcinoma; Kidney cancer

Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates f...