Association between antihypertensive medication use and kidney cancer risk: a meta-analysis accounting for hypertension
Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates f...
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Published in | BMC cancer Vol. 25; no. 1; pp. 1013 - 12 |
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Format | Journal Article |
Language | English |
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06.06.2025
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Abstract | Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension.
We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR).
In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings.
AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. |
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AbstractList | Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension.
We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR).
In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings.
AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension. We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR). In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration-response relationships supported the main findings. AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. Background Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension. Methods We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR). Results In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration-response relationships supported the main findings. Conclusions AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. Keywords: Antihypertensive drugs, Kidney cancer, Renal cell carcinoma, Hypertension, Adverse drug reaction Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension.BACKGROUNDEvidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension.We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR).METHODSWe searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR).In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings.RESULTSIn this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93-1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03-1.16 for beta-blocker, RR 1.40, 95% CI 1.12-1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20-1.55 for diuretic; and RR 1.40, 95% CI 1.13-1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings.AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration.CONCLUSIONSAHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. Abstract Background Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension. Methods We searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR). Results In this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93–1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03–1.16 for beta-blocker, RR 1.40, 95% CI 1.12–1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20–1.55 for diuretic; and RR 1.40, 95% CI 1.13–1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings. Conclusions AHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. BackgroundEvidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is available on disentangling the effects of AHTN use on KC from hypertension, which is a risk factor for KC. We aimed to identify pooled estimates for the associations between AHTN use and KC risk, independent of hypertension.MethodsWe searched for observational studies that investigated the associations between AHTN use and KC through January 2025. To identify the independent effects of AHTN from hypertension, we conducted stratified analyses with and without accounting for hypertension: any methods (matching, adjustment, or stratification/restriction) versus none. We conducted random-effects meta-analyses with robust variance estimation to calculate pooled relative risk (RR).ResultsIn this meta-analysis consisting of 39 eligible studies, AHTN use was associated with an increased risk of KC based on estimates that accounted for hypertension (RR 1.19, 95% confidence interval (CI) 0.93–1.52 for angiotensin-converting enzyme inhibitor; RR 1.15, 95% CI 1.00-1.31 for angiotensin receptor blocker; RR 1.09, 95% CI 1.03–1.16 for beta-blocker, RR 1.40, 95% CI 1.12–1.75 for calcium channel blocker (CCB); RR 1.36, 95% CI 1.20–1.55 for diuretic; and RR 1.40, 95% CI 1.13–1.75 for non-classified AHTN). Findings from duration‒response relationships supported the main findings.ConclusionsAHTN use was associated with an increased risk of KC compared to no use, even after accounting for hypertension, with the highest risk observed for CCB. Our findings highlight the potential KC risks associated with different AHTN classes, with optimal cardiovascular care remaining an important consideration. |
ArticleNumber | 1013 |
Audience | Academic |
Author | Jung, Minji Chung, Benjamin I. Langston, Marvin E. Li, Mingyi Shin, Jaekyu |
Author_xml | – sequence: 1 givenname: Minji surname: Jung fullname: Jung, Minji – sequence: 2 givenname: Mingyi surname: Li fullname: Li, Mingyi – sequence: 3 givenname: Jaekyu surname: Shin fullname: Shin, Jaekyu – sequence: 4 givenname: Benjamin I. surname: Chung fullname: Chung, Benjamin I. – sequence: 5 givenname: Marvin E. surname: Langston fullname: Langston, Marvin E. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40481406$$D View this record in MEDLINE/PubMed |
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Keywords | Hypertension Antihypertensive drugs Adverse drug reaction Renal cell carcinoma Kidney cancer |
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Snippet | Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited evidence is... Background Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited... BackgroundEvidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However, limited... Abstract Background Evidence that antihypertensive medication (AHTN) use is associated with an increased risk of kidney cancer (KC) is emerging. However,... |
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SubjectTerms | Adverse and side effects Adverse drug reaction Angiotensin Angiotensin Receptor Antagonists - adverse effects Angiotensin Receptor Antagonists - therapeutic use Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Antihypertensive drugs Antihypertensives Blood pressure Body mass index Cohort analysis Complications and side effects Diuretics Dosage and administration Drugs Estimates Humans Hypertension Hypertension - complications Hypertension - drug therapy Hypoxia Kidney cancer Kidney Neoplasms - chemically induced Kidney Neoplasms - epidemiology Medical records Meta-analysis Observational studies Observational Studies as Topic Peptidyl-dipeptidase A Prevention Renal cell carcinoma Risk Factors |
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Title | Association between antihypertensive medication use and kidney cancer risk: a meta-analysis accounting for hypertension |
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