Protein Kinase C ε Expression in Platelets from Patients with Acute Myocardial Infarction

• Published in: PloS one Vol. 7; no. 10; p. e46409
• Main Authors: Carubbi, Cecilia, Mirandola, Prisco, Mattioli, Maria, Galli, Daniela, Marziliano, Nicola, Merlini, Piera Angelica, Lina, Daniela, Notarangelo, Francesca, Cozzi, Maria Rita, Gesi, Marco, Ardissino, Diego, De Marco, Luigi, Vitale, Marco, Gobbi, Giuliana
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.10.2012; Public Library of Science (PLoS)
• Subjects: Acute coronary syndromes; Adenosine; Adenosine diphosphate; Aged; Angina pectoris; Angioplasty; Base Sequence; Biology; Blood clots; Blood platelets; Blood Platelets - enzymology; Cardiology; Case-Control Studies; Collagen; Coronary artery; Coronary artery disease; Differentiation; DNA Primers; DNA, Complementary; Female; Flow Cytometry; Gene expression; Heart attacks; Heart diseases; Humans; Kinases; Laboratories; Male; Medicine; mRNA; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - enzymology; Patients; Phosphorylation; Platelet Activation; Platelets; Protein kinase C; Protein Kinase C-epsilon - blood; Protein Kinase C-epsilon - genetics; Protein synthesis; Proteins; Real-Time Polymerase Chain Reaction; Thromboembolism; Thrombosis; Italy

Platelets play crucial roles in the pathophysiology of thrombosis and myocardial infarction. Protein kinase C ε (PKCε) is virtually absent in human platelets and its expression is precisely regulated during human megakaryocytic differentiation. On the basis of what is known on the role of platelet P...