Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model

• Published in: PLoS computational biology Vol. 17; no. 2; p. e1008257
• Main Authors: Lee, Junho, Lee, Donggu, Lawler, Sean, Kim, Yangjin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Carrying capacity; Cell proliferation; Chemokines; Clinical outcomes; Computational Biology; Computer applications; Computer Simulation; Extracellular matrix; Extracellular Traps - metabolism; Fibroblasts; Growth factors; Homeostasis; Humans; In Vitro Techniques; Interleukin-8 - antagonists & inhibitors; Leukocytes (neutrophilic); Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Mathematical models; Matrix methods; Medicine and Health Sciences; Mesenchyme; Metastases; Metastasis; Models, Biological; Motility; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - pathology; Neutrophils; Neutrophils - metabolism; Neutrophils - pathology; Receptors, Transforming Growth Factor beta - antagonists & inhibitors; Research and Analysis Methods; Secretion; Signal Transduction; Transforming Growth Factor beta - antagonists & inhibitors; Tumor cells; Tumor Microenvironment; Tumors

Lung cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by hijacking immune system for active growth and aggressive metastasis. Neutrophils, which in their original form should establish immune activities to the tumor as a first line of defense, are undermine...