14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis

• Published in: BMC plant biology Vol. 24; no. 1; p. 1148
• Main Authors: Liu, Ting, Zheng, Yuping, Zhou, Shunkang, Wang, Yao, Lei, Xue, Xie, Lijuan, Lin, Qingqi, Chang, Changqing, Xiao, Shi, Qiu, Rongliang, Qi, Hua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.11.2024; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; 14-3-3 protein; 14-3-3 proteins; 14-3-3 Proteins - genetics; 14-3-3 Proteins - metabolism; Arabidopsis - genetics; Arabidopsis - metabolism; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; Autophagy; Autophagy-related protein 6 (ATG6); Autophagy-Related Proteins - genetics; Autophagy-Related Proteins - metabolism; Biosynthesis; Botanical research; Carbon; Cellular control mechanisms; Chlorophyll; Defective mutant; Degradation; Destabilization; Enzymes; Eukaryotes; eukaryotic cells; Genetic aspects; Homeostasis; In vivo methods and tests; Kinases; leaves; Molecular modelling; mutants; Nitrogen; Nutrients; phenotype; Phenotypes; phosphatidylinositol 3-kinase; Phosphorylation; Physiological aspects; Proteins; Proteolysis; RING finger domains; Roles; Scaffolds; Senescence; Signal transduction; starvation; Translocation; tumor necrosis factor receptors; Ubiquitin-protein ligase; Ubiquitination; China; Arabidopsis thaliana; 14-3-3 proteins; Ubiquitination; Autophagy-related protein 6 (ATG6); Autophagy

Autophagy is a conserved cellular process crucial for recycling cytoplasmic components and maintaining cellular homeostasis in eukaryotes. During autophagy, the formation of a protein complex involving AUTOPHAGY-RELATED PROTEIN 6 (ATG6) and phosphatidylinositol 3-kinase is pivotal for recruiting pro...