Expression and role of c-myc in chondrocytes undergoing endochondral ossification

• Published in: The Journal of biological chemistry Vol. 268; no. 13; pp. 9645 - 9652
• Main Authors: IWAMOTO, M, YAGAMI, K, VALLE, P. L, OLSEN, B. R, PETROPOULOS, C. J, EWERT, D. L, PACIFICI, M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 05.05.1993
• Subjects: Animals; Autoradiography; Base Sequence; Biological and medical sciences; Blotting, Northern; Cartilage - embryology; Cartilage - physiology; Cell differentiation, maturation, development, hematopoiesis; Cell Division - drug effects; Cell physiology; Cells, Cultured; Chick Embryo; Collagen - genetics; DNA - biosynthesis; DNA - genetics; DNA Replication; Exons; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes, myc; In Situ Hybridization; Kinetics; Molecular and cellular biology; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotides, Antisense - pharmacology; Osteogenesis; Promoter Regions, Genetic; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sternum; Thionucleotides - pharmacology; Thymidine - metabolism; Transcription, Genetic; Tritium; Cell proliferation; Vertebrata; Chondrocyte; Collagen; Chicken; Aves; Cell differentiation; Gene expression; Ossification

To analyze the relationship between c-myc gene expression and chondrocyte proliferation and maturation during endochondral ossification, Day 18-19 chick embryo sterna were pulse-labeled with [3H]thymidine, and serial sections were processed for autoradiography and in situ hybridization. Proliferatin...