CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 242; pp. 105 - 121
• Main Authors: Pereira, MARIA J., VRANIC, MILICA, KAMBLE, PRASAD G., JERNOW, HENNING, KRISTÓFI, ROBIN, HOLBIKOVA, EMA, SKRTIC, STANKO, KULLBERG, JOEL, SVENSSON, MARIA K., HETTY, SUSANNE, ERIKSSON, JAN W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022
• Subjects: Adipocytes - metabolism; ADIPOQ=Adiponectin; Adipose Tissue - metabolism; AT=Adipose tissue; CDKN2C=Cyclin-Dependent Kinase Inhibitor 2C; CEBPA=CCAAT Enhancer Binding Protein Alpha; Cyclin-Dependent Kinase Inhibitor p18 - metabolism; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Endocrinology and Diabetes; Endokrinologi och diabetes; FASN=Fatty Acid Synthase; GWAS=Genome-wide association study; Humans; Insulin Resistance; Lipids; MRI=Magnetic resonance imaging; OAT=Omental adipose tissue; Obesity - genetics; Obesity - metabolism; Obesity, Abdominal; PPARG=Peroxisome Proliferator-Activated Receptor Gamma; RNP=Ribonucleoprotein; SAT=Subcutaneous adipose tissue; sgRNA=Single-guide RNA; SVF=Stromal vascular fraction; T2D=Type II diabetes; VAT=Visceral adipose tissue; WHR=Waist-hip ratio; sgRNA=Single-guide RNA; SAT=Subcutaneous adipose tissue; OAT=Omental adipose tissue; T2D=Type II diabetes; VAT=Visceral adipose tissue; ADIPOQ=Adiponectin; RNP=Ribonucleoprotein; WHR=Waist-hip ratio; AT=Adipose tissue; MRI=Magnetic resonance imaging; CDKN2C=Cyclin-Dependent Kinase Inhibitor 2C; CEBPA=CCAAT Enhancer Binding Protein Alpha; FASN=Fatty Acid Synthase; SVF=Stromal vascular fraction; PPARG=Peroxisome Proliferator-Activated Receptor Gamma; GWAS=Genome-wide association study

CDKN2C/p18 (Cyclin-Dependent Kinase Inhibitor 2C) is a cell growth regulator that controls cell cycle progression and has previously been associated with increased risk for type II diabetes (T2D) and reduced peripheral adipose tissue (AT) storage capacity. This study explored the role of CDKN2C in A...