Associations between White Matter Hyperintensities and β Amyloid on Integrity of Projection, Association, and Limbic Fiber Tracts Measured with Diffusion Tensor MRI

• Published in: PloS one Vol. 8; no. 6; p. e65175
• Main Authors: Chao, Linda L., DeCarli, Charles, Kriger, Stephen, Truran, Diana, Zhang, Yu, Laxamana, Joel, Villeneuve, Sylvia, Jagust, William J., Sanossian, Nerses, Mack, Wendy J., Chui, Helena C., Weiner, Michael W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.06.2013; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; Aging; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Anisotropy; Apolipoprotein E; Apolipoprotein E4; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; Arteriosclerosis; Atherosclerosis; Biology; Blood vessels; Brain; Brain Mapping; Brain research; Cingulum; Cognitive ability; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - genetics; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Corona; Corpus callosum; Covariance; Dementia; Dementia disorders; Deposition; Diffusion; Diffusion Tensor Imaging; Disease; Emission analysis; Female; Fornix; Gene Expression; Health care; Humans; Hypertension; Integrity; Limbic System - metabolism; Limbic System - pathology; Longitudinal Studies; Magnetic resonance; Magnetic resonance imaging; Male; Medical imaging; Medicine; Multivariate Analysis; Neuroimaging; Neurology; Neuropsychological Tests; Neurosciences; NMR; Nuclear magnetic resonance; Older people; Parahippocampal gyrus; Parenchyma; Pathology; Positron emission; Positron emission tomography; Risk analysis; Risk factors; Stroke; Substantia alba; Tomography; Traumatic brain injury; Veterans; Los Angeles California; San Francisco California; California; United States > US

The goal of this study was to assess the relationship between Aβ deposition and white matter pathology (i.e., white matter hyperintensities, WMH) on microstructural integrity of the white matter. Fifty-seven participants (mean age: 78±7 years) from an ongoing multi-site research program who spanned...