Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts
Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is nec...
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Published in | PloS one Vol. 10; no. 10; p. e0140249 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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08.10.2015
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Abstract | Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors. |
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AbstractList | Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts’ structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors. |
Author | Chang, Fang-Rong Wu, Wei-Chiang Chen, Chun-Lin Wu, Deng-Chyang Yang, Pei-Hua Huang, Yaw-Bin Duh, Tsai-Hui Chen, Ying-Pin Lin, Ming-Wei Kao, Yu-Chen |
AuthorAffiliation | 8 Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC 7 Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC 5 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC 4 Graduate Institute of Nature Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC University of British Columbia, CANADA 2 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan, ROC 1 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC 3 Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC 6 Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC |
AuthorAffiliation_xml | – name: 7 Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – name: 3 Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – name: University of British Columbia, CANADA – name: 2 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan, ROC – name: 6 Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC – name: 4 Graduate Institute of Nature Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – name: 5 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – name: 1 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC – name: 8 Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC |
Author_xml | – sequence: 1 givenname: Chun-Lin surname: Chen fullname: Chen, Chun-Lin organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 2 givenname: Ying-Pin surname: Chen fullname: Chen, Ying-Pin organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC – sequence: 3 givenname: Ming-Wei surname: Lin fullname: Lin, Ming-Wei organization: Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 4 givenname: Yaw-Bin surname: Huang fullname: Huang, Yaw-Bin organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC; Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 5 givenname: Fang-Rong surname: Chang fullname: Chang, Fang-Rong organization: Graduate Institute of Nature Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 6 givenname: Tsai-Hui surname: Duh fullname: Duh, Tsai-Hui organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 7 givenname: Deng-Chyang surname: Wu fullname: Wu, Deng-Chyang organization: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 8 givenname: Wei-Chiang surname: Wu fullname: Wu, Wei-Chiang organization: Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC – sequence: 9 givenname: Yu-Chen surname: Kao fullname: Kao, Yu-Chen organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC – sequence: 10 givenname: Pei-Hua surname: Yang fullname: Yang, Pei-Hua organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: C-LC. Performed the experiments: C-LC Y-PC. Analyzed the data: C-LC Y-PC Y-CK P-HY. Contributed reagents/materials/analysis tools: M-WL Y-BH F-RC T-HD D-CW W-CW. Wrote the paper: C-LC. |
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Mol Cell Proteomics doi: 10.1074/mcp.M110.007146 contributor: fullname: YZ Zheng |
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Snippet | Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated... |
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SubjectTerms | Alcohols Anticancer properties Antifungal agents Apoptosis Cancer Caveolae Cell Line, Tumor Cell survival Chemistry Cholesterol Clathrin Endocytosis Epidermal growth factor Euphorbia - chemistry Euphorbia tirucalli Fibronectins - genetics Fibronectins - metabolism Gastric cancer Gene Expression Humans Inflammation Kinases Lanosterol - analogs & derivatives Lanosterol - pharmacology Lipid rafts Lipids Medical research Membrane Microdomains - metabolism Natural products Pharmaceutical sciences Pharmacology Pharmacy Phosphorylation Plant Extracts - pharmacology Plasma Protein Processing, Post-Translational Protein Transport Proteins Proteolysis Rafts Receptors Receptors, Transforming Growth Factor beta - metabolism Signal transduction Signaling Stem cells Stomach cancer Stomach Neoplasms Structure-function relationships Transcriptional Activation Transforming growth factor Transforming Growth Factor beta - physiology Transforming growth factor-b Tumors |
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Title | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts |
URI | https://www.ncbi.nlm.nih.gov/pubmed/26448474 https://www.proquest.com/docview/1720192816 https://search.proquest.com/docview/1721361297 https://pubmed.ncbi.nlm.nih.gov/PMC4598150 https://doaj.org/article/86588a0090844f5ea3aa33cb50d4ff74 http://dx.doi.org/10.1371/journal.pone.0140249 |
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