Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts

Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is nec...

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Published inPloS one Vol. 10; no. 10; p. e0140249
Main Authors Chen, Chun-Lin, Chen, Ying-Pin, Lin, Ming-Wei, Huang, Yaw-Bin, Chang, Fang-Rong, Duh, Tsai-Hui, Wu, Deng-Chyang, Wu, Wei-Chiang, Kao, Yu-Chen, Yang, Pei-Hua
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.10.2015
Public Library of Science (PLoS)
Subjects
Alcohols
Anticancer properties
Antifungal agents
Apoptosis
Cancer
Caveolae
Cell Line, Tumor
Cell survival
Chemistry
Cholesterol
Clathrin
Endocytosis
Epidermal growth factor
Euphorbia - chemistry
Euphorbia tirucalli
Fibronectins - genetics
Fibronectins - metabolism
Gastric cancer
Gene Expression
Humans
Inflammation
Kinases
Lanosterol - analogs & derivatives
Lanosterol - pharmacology
Lipid rafts
Lipids
Medical research
Membrane Microdomains - metabolism
Natural products
Pharmaceutical sciences
Pharmacology
Pharmacy
Phosphorylation
Plant Extracts - pharmacology
Plasma
Protein Processing, Post-Translational
Protein Transport
Proteins
Proteolysis
Rafts
Receptors
Receptors, Transforming Growth Factor beta - metabolism
Signal transduction
Signaling
Stem cells
Stomach cancer
Stomach Neoplasms
Structure-function relationships
Transcriptional Activation
Transforming growth factor
Transforming Growth Factor beta - physiology
Transforming growth factor-b
Tumors
Taiwan
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Abstract Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.
AbstractList Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts’ structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.
Author Chang, Fang-Rong
Wu, Wei-Chiang
Chen, Chun-Lin
Wu, Deng-Chyang
Yang, Pei-Hua
Huang, Yaw-Bin
Duh, Tsai-Hui
Chen, Ying-Pin
Lin, Ming-Wei
Kao, Yu-Chen
AuthorAffiliation 8 Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
7 Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
5 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
4 Graduate Institute of Nature Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
University of British Columbia, CANADA
2 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan, ROC
1 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC
3 Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
6 Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
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  givenname: Pei-Hua
  surname: Yang
  fullname: Yang, Pei-Hua
  organization: Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26448474$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2015 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2015 Chen et al 2015 Chen et al
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: C-LC. Performed the experiments: C-LC Y-PC. Analyzed the data: C-LC Y-PC Y-CK P-HY. Contributed reagents/materials/analysis tools: M-WL Y-BH F-RC T-HD D-CW W-CW. Wrote the paper: C-LC.
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SSID ssj0053866
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Snippet Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated...
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StartPage e0140249
SubjectTerms Alcohols
Anticancer properties
Antifungal agents
Apoptosis
Cancer
Caveolae
Cell Line, Tumor
Cell survival
Chemistry
Cholesterol
Clathrin
Endocytosis
Epidermal growth factor
Euphorbia - chemistry
Euphorbia tirucalli
Fibronectins - genetics
Fibronectins - metabolism
Gastric cancer
Gene Expression
Humans
Inflammation
Kinases
Lanosterol - analogs & derivatives
Lanosterol - pharmacology
Lipid rafts
Lipids
Medical research
Membrane Microdomains - metabolism
Natural products
Pharmaceutical sciences
Pharmacology
Pharmacy
Phosphorylation
Plant Extracts - pharmacology
Plasma
Protein Processing, Post-Translational
Protein Transport
Proteins
Proteolysis
Rafts
Receptors
Receptors, Transforming Growth Factor beta - metabolism
Signal transduction
Signaling
Stem cells
Stomach cancer
Stomach Neoplasms
Structure-function relationships
Transcriptional Activation
Transforming growth factor
Transforming Growth Factor beta - physiology
Transforming growth factor-b
Tumors
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Title Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts
URI https://www.ncbi.nlm.nih.gov/pubmed/26448474
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http://dx.doi.org/10.1371/journal.pone.0140249
Volume 10
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