Kharon1 null mutants of Leishmania mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages

• Published in: PloS one Vol. 10; no. 8; p. e0134432
• Main Authors: Tran, Khoa D, Vieira, Danielle P, Sanchez, Marco A, Valli, Jessica, Gluenz, Eva, Landfear, Scott M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.08.2015; Public Library of Science (PLoS)
• Subjects: Amastigotes; Animals; Cell cycle; Cell division; Chemoreception; Cytokinesis; Cytokinesis - genetics; Cytoskeletal Proteins - genetics; Eukaryotes; Flagella; Flagella - genetics; Flagella - parasitology; Glucose; Glucose Transport Proteins, Facilitative - genetics; Glucose transporter; Immunology; Insects; Intracellular; Leishmania; Leishmania donovani; Leishmania major; Leishmania mexicana; Leishmania mexicana - genetics; Leishmania mexicana - pathogenicity; Leishmaniasis; Leishmaniasis - genetics; Leishmaniasis - parasitology; Leishmaniasis - pathology; Macrophages; Macrophages - parasitology; Mice; Mutants; Mutation; Organelles; Parasites; Parasitic diseases; Promastigotes; Proteins; Protozoa; Protozoan Proteins - genetics; Signal transduction; Vector-borne diseases; Viability; Oregon; United Kingdom > UK; United States > US

In a variety of eukaryotes, flagella play important roles both in motility and as sensory organelles that monitor the extracellular environment. In the parasitic protozoan Leishmania mexicana, one glucose transporter isoform, LmxGT1, is targeted selectively to the flagellar membrane where it appears...