Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)

• Published in: PloS one Vol. 10; no. 8; p. e0136764
• Main Authors: Webster, A. Francina, Chepelev, Nikolai, Gagné, Rémi, Kuo, Byron, Recio, Leslie, Williams, Andrew, Yauk, Carole L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.08.2015; Public Library of Science (PLoS)
• Subjects: Animals; Benchmarking; Benchmarks; Bioassays; Bioinformatics; Bone mineral density; Cancer; Carcinogens; Carcinogens - administration & dosage; Carcinogens - toxicity; Chemicals; Deoxyribonucleic acid; DNA; DNA microarrays; Dose-Response Relationship, Drug; Environmental health; Female; Filtration; Furans - administration & dosage; Furans - toxicity; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gene sequencing; Genomics; Genomics - methods; Genomics - statistics & numerical data; Health risk assessment; Liver; Liver - drug effects; Liver - physiology; Liver cancer; Mathematical models; Mice; Mice, Inbred Strains; Models, Theoretical; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Regulatory agencies; Ribonucleic acid; Risk assessment; Risk Assessment - methods; RNA; Science; Sequence Analysis, RNA - methods; Statistical analysis; Studies; Toxicogenetics - methods; Transcription; Canada; United States > US

Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how to distill the complex data produced by high-content, multi-dose gene expression studies into quantitative information. It has been proposed t...