Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD) - Webster, A. Francina; Chepelev, Nikolai; Gagné, Rémi; Kuo, Byron; Recio, Leslie; Williams, Andrew; Yauk, Carole L. (PloS one, 2015)
Keywords: Animals; Benchmarking; Benchmarks; Bioassays; Bioinformatics; Bone mineral density; Cancer; Carcinogens; Carcinogens - administration & dosage; Carcinogens - toxicity; Chemicals; Deoxyribonucleic acid; DNA; DNA microarrays; Dose-Response Relationship, Drug; Environmental health; Female; Filtration; Furans - administration & dosage; Furans - toxicity; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gene sequencing; Genomics; Genomics - methods; Genomics - statistics & numerical data; Health risk assessment; Liver; Liver - drug effects; Liver - physiology; Liver cancer; Mathematical models; Mice; Mice, Inbred Strains; Models, Theoretical; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Regulatory agencies; Ribonucleic acid; Risk assessment; Risk Assessment - methods; RNA; Science; Sequence Analysis, RNA - methods; Statistical analysis; Studies; Toxicogenetics - methods; Transcription; Canada; United States--US