Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

• Published in: PloS one Vol. 8; no. 2; p. e56527
• Main Authors: Hardy, Gareth A. D., Sieg, Scott, Rodriguez, Benigno, Anthony, Donald, Asaad, Robert, Jiang, Wei, Mudd, Joseph, Schacker, Timothy, Funderburg, Nicholas T., Pilch-Cooper, Heather A., Debernardo, Robert, Rabin, Ronald L., Lederman, Michael M., Harding, Clifford V.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.02.2013; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Activation; AIDS; Antigens; Antiviral Agents - administration & dosage; Bioassays; Biological activity; Biology; Blood; CD38 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - virology; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Chief executive officers; Chronic infection; Correlation; Dendritic cells; Drug therapy; Gene expression; Hepacivirus - drug effects; Hepacivirus - pathogenicity; Hepatitis; Hepatitis C; Hepatitis C - blood; Hepatitis C - drug therapy; HIV; HIV Infections - blood; HIV Infections - immunology; HIV Infections - pathology; HIV-1 - immunology; HIV-1 - pathogenicity; Human immunodeficiency virus; Humans; Immunity, Active; Infections; Infectious diseases; Interferon; Interferon-alpha - administration & dosage; Interferon-alpha - blood; Interferon-alpha - immunology; Leukocytes; Lymph nodes; Lymph Nodes - drug effects; Lymph Nodes - metabolism; Lymphocytes; Lymphocytes T; Medicine; mRNA; Pathogenesis; Pathology; Peripheral blood; Ribavirin; Ribavirin - administration & dosage; Ribonucleic acid; RNA; Viruses; Cleveland Ohio; United States > US; Ohio

Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated IFN-I species has not been conclusively identified, its source remains obscure a...