DAMP-mediated autophagy contributes to drug resistance

• Published in: Autophagy Vol. 7; no. 1; pp. 112 - 114
• Main Authors: Liu, Liying, Yang, Minghua, Kang, Rui, Wang, Zhuo, Zhao, Yiming, Yu, Yan, Xie, Min, Yin, Xiaocheng, Livesey, Kristen M., Loze, Michael T., Tang, Daolin, Cao, Lizhi
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2011; Landes Bioscience
• Subjects: Autophagic Punctum; Autophagy; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cycle; Drug Resistance, Neoplasm; HMGB1 Protein - metabolism; Humans; Landes; Leukemia - enzymology; Leukemia - pathology; MAP Kinase Signaling System; Models, Biological; Organogenesis; Phosphatidylinositol 3-Kinases - metabolism; Proteins; Receptors, Pattern Recognition - metabolism

Damage-associated molecular pattern molecules (DAMPs) are cellularly derived molecules that can initiate and perpetuate immune responses following trauma, ischemia and other types of tissue damage in the absence of pathogenic infection. High mobility group box 1 (HMGB1) is a prototypical DAMP and is...