In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity - Thomann, Marco; Schlothauer, Tilman; Dashivets, Tetyana; Malik, Sebastian; Avenal, Cecile; Bulau, Patrick; Rüger, Petra; Reusch, Dietmar (PloS one, 2015)
Keywords: Acids; Affinity chromatography; Antibody-Dependent Cell Cytotoxicity; Binding; Binding Sites; Biochemistry; Bioengineering; Biological activity; Biological effects; Chromatography; Enzymes; Fc receptors; Galactose - metabolism; Gene Expression; Glycan; Glycosylation; Glycosyltransferase; HEK293 Cells; Humans; Immunoglobulin G; Immunoglobulin G - chemistry; Immunoglobulin G - genetics; Immunoglobulin G - metabolism; Immunoglobulins; Immunology; Molecular biology; Monoclonal antibodies; Polysaccharides; Protein Binding; Protein Engineering; Proteins; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Receptors; Receptors, IgG - chemistry; Receptors, IgG - genetics; Receptors, IgG - metabolism; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Sialic Acids - metabolism; Sialyltransferases - genetics; Sialyltransferases - metabolism; Studies; Sugar; Surface plasmon resonance; Germany