Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress

• Published in: Psychoneuroendocrinology Vol. 116; p. 104632
• Main Authors: Ridout, Kathryn K., Coe, Jesse L., Parade, Stephanie H., Marsit, Carmen J., Kao, Hung-Teh, Porton, Barbara, Carpenter, Linda L., Price, Lawrence H., Tyrka, Audrey R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2020
• Subjects: Adult; Adverse Childhood Experiences; Adversity; DNA Copy Number Variations - genetics; DNA Methylation - physiology; DNA, Mitochondrial - genetics; Early life stress; Female; Glucocorticoid receptor methylation; Humans; Male; Middle Aged; Mitochondrial DNA copy number; Neurosecretory Systems - metabolism; Organelle Biogenesis; Receptors, Glucocorticoid - metabolism; Signal Transduction; Stress, Psychological - metabolism; Trauma; Young Adult; Mitochondrial DNA copy number; Adversity; Early life stress; Glucocorticoid receptor methylation; Adverse childhood experiences; Trauma

•Methylation of the glucocorticoid receptor promotor region (NR3C1) significantly mediated the relation between early adversity and mitochondrial DNA copy number (mtDNAcn).•This result suggests NR3C1 methylation may be an important mechanism linking early adversity and changes in mtDNAcn, a marker o...