LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis

• Published in: PloS one Vol. 8; no. 8; p. e73861
• Main Authors: Cimato, Thomas R, Palka, Beth A, Lang, Jennifer K, Young, Rebeccah F
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.08.2013; Public Library of Science (PLoS)
• Subjects: Acute coronary syndromes; Adult; Antigens, CD34 - immunology; Arteriosclerosis; Atherosclerosis; Blood; Buffy coat; Cardiovascular disease; CD34 antigen; Cell Proliferation; Cell surface; Cells (biology); Cholesterol; Cholesterol, LDL - physiology; Coronary vessels; Correlation; CXCR4 protein; Cytokines; Cytometry; Differentiation; Enzyme-linked immunosorbent assay; Female; Flow Cytometry; Granulocyte colony-stimulating factor; Granulocyte Colony-Stimulating Factor - physiology; Granulocyte colony-stimulating factor receptors; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - immunology; Humans; Hypercholesterolemia; Immune system; Inflammation; Interleukin 17; Interleukin-17 - physiology; Leukocyte migration; Leukocytes; Leukocytes (granulocytic); Lipids; Low density lipoprotein; Male; Medicine; Metabolism; Middle Aged; Monocytes; Neutrophils; Pathogenesis; Phagocytosis; Population studies; Proteins; SDF-1 protein; Statins; Stem cells; New York; United States > US

Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to...