LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis

Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 8; no. 8; p. e73861
Main Authors Cimato, Thomas R, Palka, Beth A, Lang, Jennifer K, Young, Rebeccah F
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 26.08.2013
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. We performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. The quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r(2)=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r(2)=0.0683, p < 0.05), and its upstream regulator IL-17 (r(2)=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. Our findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
AbstractList BACKGROUND: Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. METHODS: We performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. RESULTS: The quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r(2)=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r(2)=0.0683, p < 0.05), and its upstream regulator IL-17 (r(2)=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. CONCLUSIONS: Our findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. Methods We performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. Results The quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r2=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r2=0.0683, p < 0.05), and its upstream regulator IL-17 (r2=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. Conclusions Our findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
BACKGROUNDHypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. METHODSWe performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. RESULTSThe quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r(2)=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r(2)=0.0683, p < 0.05), and its upstream regulator IL-17 (r(2)=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. CONCLUSIONSOur findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. We performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. The quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r(2)=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r(2)=0.0683, p < 0.05), and its upstream regulator IL-17 (r(2)=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. Our findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differentiation to granulocytes and monocytes. The objective of our study was to determine how cholesterol levels affect HSPC quantity in humans. Methods We performed a blinded, randomized hypothesis generating study in human subjects (n=12) treated sequentially with statins of differing potencies to vary lipid levels. CD34+ HSPC levels in blood were measured by flow cytometry. Hematopoietic colony forming assays confirmed the CD34+ population studied as HSPCs with multlineage differentiation potential. Mobilizing cytokine levels were measured by ELISA. Results The quantity of HSPCs was 0.15 ± 0.1% of buffy coat leukocytes. We found a weak, positive correlation between CD34+ HSPCs and both total and LDL cholesterol levels (r2=0.096, p < 0.025). Additionally, we tested whether cholesterol modulates CD34+ HSPCs through direct effects or on the levels of mobilizing cytokines. LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. LDL cholesterol also increased proliferation of CD34+ HSPCs (28 ± 5.7%, n=6, p < 0.03). Finally, the HSPC mobilizing cytokine G-CSF (r2=0.0683, p < 0.05), and its upstream regulator IL-17 (r2=0.0891, p < 0.05) both correlated positively with LDL cholesterol, while SDF-1 levels were not significantly affected. Conclusions Our findings support a model where LDL cholesterol levels positively correlate with CD34+ HSPC levels in humans through effects on the levels of G-CSF via IL-17 promoting mobilization of HSPCs, and by direct effects of LDL cholesterol on HSPC proliferation. The findings are provocative of further study to determine if HSPCs, like cholesterol levels, are linked to CVD events.
Author Palka, Beth A
Young, Rebeccah F
Lang, Jennifer K
Cimato, Thomas R
AuthorAffiliation Northwestern University, United States of America
Department of Medicine/Division of Cardiovascular Medicine, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Clinical and Translational Research Center, Buffalo, New York, United States of America
AuthorAffiliation_xml – name: Department of Medicine/Division of Cardiovascular Medicine, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Clinical and Translational Research Center, Buffalo, New York, United States of America
– name: Northwestern University, United States of America
Author_xml – sequence: 1
  givenname: Thomas R
  surname: Cimato
  fullname: Cimato, Thomas R
  email: tcimato@buffalo.edu
  organization: Department of Medicine/Division of Cardiovascular Medicine, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Clinical and Translational Research Center, Buffalo, New York, USA. tcimato@buffalo.edu
– sequence: 2
  givenname: Beth A
  surname: Palka
  fullname: Palka, Beth A
– sequence: 3
  givenname: Jennifer K
  surname: Lang
  fullname: Lang, Jennifer K
– sequence: 4
  givenname: Rebeccah F
  surname: Young
  fullname: Young, Rebeccah F
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23991206$$D View this record in MEDLINE/PubMed
BookMark eNptkl2L1DAUhousuB_6D0QD3gjSMd-Z3gjSdXcHCgqr1yFNT6cd0mZMWtF_b2anu-yKV0lO3vPknJz3PDsZ_QhZ9prgFWGKfNz5OYzGrfYpvMJYsbUkz7IzUjCaS4rZyaP9aXYe4w5jkUTyRXZKWVEQiuVZBtVlhWznHcQJgndo8M3szAQRdfNgRlReMv4B3dx-KyOauuDnbYegbcFOEfkR7VNO30IwU59OZmySCNCmyolC13l5e4XM7z6-zJ63xkV4tawX2Y-rL9_Lm7z6er0pP1e5FVROec2waKhUTGJODQclW2VrRbAQzGDAawu2LZqCq5ozJgxVwlpi15ZaRaXl7CJ7e-TunY96-aGoCadrLA-UpNgcFY03O70P_WDCH-1Nr-8CPmy1CVNvHWhrBKkNEZSShq_pAaEaUSjGGHADkFifltfmeoDGwjgF455An96Mfae3_pdmSrA0ggR4vwCC_zmnCeihjxacMyP4-a7ughIumUrSd_9I_98dP6ps8DEGaB-KIVgfXHOfpQ-u0YtrUtqbx408JN3bhP0F6FS_GA
CitedBy_id crossref_primary_10_1182_bloodadvances_2019000923
crossref_primary_10_1002_cyto_b_21354
crossref_primary_10_1016_j_transci_2021_103074
crossref_primary_10_1089_jir_2019_0166
crossref_primary_10_3390_nu15010183
crossref_primary_10_5966_sctm_2013_0205
crossref_primary_10_3389_fimmu_2021_663412
crossref_primary_10_3390_ijms22073505
crossref_primary_10_1371_journal_pone_0284998
crossref_primary_10_3390_life13071588
crossref_primary_10_1097_JCP_0000000000000830
crossref_primary_10_1186_2001_1326_3_14
crossref_primary_10_1007_s00441_022_03592_2
crossref_primary_10_1080_08830185_2019_1645138
crossref_primary_10_1161_ATVBAHA_116_308834
crossref_primary_10_1097_MOT_0000000000000381
crossref_primary_10_1111_ajt_13350
crossref_primary_10_3389_fendo_2019_00204
crossref_primary_10_1038_s42255_023_00846_3
crossref_primary_10_1093_eurheartj_ehw246
crossref_primary_10_7717_peerj_764
crossref_primary_10_1128_jvi_00758_23
crossref_primary_10_1093_eurheartj_ehab465
crossref_primary_10_1038_s41598_024_55575_8
crossref_primary_10_3390_ijms24108757
crossref_primary_10_1159_000515281
crossref_primary_10_1172_JCI94027
crossref_primary_10_1016_j_cca_2014_01_012
crossref_primary_10_1016_j_pharmthera_2018_08_012
crossref_primary_10_1002_advs_202102669
Cites_doi 10.1126/science.1191536
10.1016/j.arcmed.2003.08.004
10.1210/me.2009-0507
10.1038/nature11260
10.1038/nrd3794
10.1038/nature07021
10.1016/j.cell.2009.05.046
10.1371/journal.pone.0047286
10.1161/01.ATV.0000156877.94472.a5
10.1016/j.immuni.2005.01.011
10.1016/j.amjmed.2011.11.013
10.1016/j.cell.2007.09.047
10.1161/01.CIR.97.18.1837
10.1016/j.stem.2012.04.024
10.1182/blood-2009-08-240580
10.1038/ni.1610
10.1182/blood-2004-05-1831
10.1084/jem.183.6.2593
10.1126/science.1230719
10.1016/j.tem.2012.10.008
10.1161/CIRCRESAHA.113.301086
ContentType Journal Article
Copyright 2013 Cimato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2013 Cimato et al 2013 Cimato et al
Copyright_xml – notice: 2013 Cimato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2013 Cimato et al 2013 Cimato et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PIMPY
PQEST
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0073861
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
Technology Collection
Technology Research Database
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Agricultural Science Database
MEDLINE - Academic
MEDLINE

Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
DocumentTitleAlternate Cholesterol Modulates CD34+ HSPCs in Humans
EISSN 1932-6203
Editor Ardehali, Hossein
Editor_xml – sequence: 1
  givenname: Hossein
  surname: Ardehali
  fullname: Ardehali, Hossein
EndPage e73861
ExternalDocumentID 1428060553
oai_doaj_org_article_ca51ba15221d48228067d597333e4aee
3055519901
10_1371_journal_pone_0073861
23991206
Genre Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations New York
United States--US
GeographicLocations_xml – name: New York
– name: United States--US
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RIG
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
CITATION
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PQEST
PQUKI
RC3
7X8
5PM
AFPKN
AAPBV
ABPTK
ID FETCH-LOGICAL-c526t-b305d26736042a4e76f7cb710553a0e08cecf9d947b4335a275cc1c8c2c726c43
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Sun Nov 05 00:20:52 EDT 2023
Tue Oct 22 15:13:01 EDT 2024
Tue Sep 17 21:34:02 EDT 2024
Fri Oct 25 02:02:34 EDT 2024
Sat Nov 09 14:41:59 EST 2024
Thu Nov 21 20:45:53 EST 2024
Tue Oct 15 23:47:05 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c526t-b305d26736042a4e76f7cb710553a0e08cecf9d947b4335a275cc1c8c2c726c43
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Conceived and designed the experiments: TRC. Performed the experiments: TRC BAP JKL RFY. Analyzed the data: TRC JKL. Contributed reagents/materials/analysis tools: TRC. Wrote the manuscript: TRC.
Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753239/
PMID 23991206
PQID 1428060553
PQPubID 1436336
ParticipantIDs plos_journals_1428060553
doaj_primary_oai_doaj_org_article_ca51ba15221d48228067d597333e4aee
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3753239
proquest_miscellaneous_1429214637
proquest_journals_1428060553
crossref_primary_10_1371_journal_pone_0073861
pubmed_primary_23991206
PublicationCentury 2000
PublicationDate 2013-08-26
PublicationDateYYYYMMDD 2013-08-26
PublicationDate_xml – month: 08
  year: 2013
  text: 2013-08-26
  day: 26
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2013
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References 20009035 - Blood. 2010 May 13;115(19):3886-94
23572498 - Circ Res. 2013 May 24;112(11):1456-65
9841303 - N Engl J Med. 1998 Nov 5;339(19):1349-57
19632178 - Cell. 2009 Jul 23;138(2):271-85
18454151 - Nat Immunol. 2008 Jun;9(6):641-9
9603539 - Circulation. 1998 May 12;97(18):1837-47
23228326 - Trends Endocrinol Metab. 2013 Mar;24(3):129-36
8676080 - J Exp Med. 1996 Jun 1;183(6):2593-603
18045540 - Cell. 2007 Nov 30;131(5):994-1008
20688981 - Science. 2010 Sep 10;329(5997):1345-8
23144813 - PLoS One. 2012;7(11):e47286
18469800 - Nature. 2008 Jul 17;454(7202):350-2
15662026 - Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):658-70
22862945 - Cell Stem Cell. 2012 Aug 3;11(2):195-206
23023676 - Nat Rev Drug Discov. 2012 Oct;11(10):763-76
20203100 - Mol Endocrinol. 2010 May;24(5):923-9
14734087 - Arch Med Res. 2003 Nov-Dec;34(6):476-88
15345590 - Blood. 2005 Jan 1;105(1):199-206
15780986 - Immunity. 2005 Mar;22(3):285-94
22387091 - Am J Med. 2012 May;125(5):440-6
23307733 - Science. 2013 Jan 11;339(6116):161-6
22763456 - Nature. 2012 Jul 19;487(7407):325-9
H Mayani (ref15) 2003; 34
CM Minder (ref2) 2012; 125
S Jaiswal (ref16) 2009; 138
O Soehnlein (ref3) 2013; 24
L Jin (ref22) 2010; 24
S Massberg (ref4) 2007; 131
M Westerterp (ref11) 2013; 112
AE Boitano (ref14) 2010; 329
BS Coller (ref7) 2005; 25
AL Gomes (ref8) 2010; 115
(ref12) 1998; 339
FK Swirski (ref1) 2013; 339
L Yang (ref20) 2008; 454
P Dutta (ref6) 2013; 487
PWF Wilson (ref13) 1998; 97
M Westerterp (ref10) 2012; 11
Y Feng (ref9) 2012; 7
F Fossiez (ref17) 1996; 183
P Miossec (ref19) 2012; 11
M Massa (ref5) 2005; 105
MA Stark (ref18) 2005; 22
N Manel (ref21) 2008; 9
References_xml – volume: 329
  start-page: 1345
  year: 2010
  ident: ref14
  article-title: Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
  publication-title: Science
  doi: 10.1126/science.1191536
  contributor:
    fullname: AE Boitano
– volume: 34
  start-page: 476
  year: 2003
  ident: ref15
  article-title: Biology of human hematopoietic stem and progenitor cells present in circulation
  publication-title: Arch Med Res
  doi: 10.1016/j.arcmed.2003.08.004
  contributor:
    fullname: H Mayani
– volume: 24
  start-page: 923
  year: 2010
  ident: ref22
  article-title: Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ
  publication-title: Mol Endocrinol
  doi: 10.1210/me.2009-0507
  contributor:
    fullname: L Jin
– volume: 487
  start-page: 325
  year: 2013
  ident: ref6
  article-title: Myocardial infarction accelerates atherosclerosis
  publication-title: Nature
  doi: 10.1038/nature11260
  contributor:
    fullname: P Dutta
– volume: 11
  start-page: 763
  year: 2012
  ident: ref19
  article-title: Targeting IL-17 and TH17 cells in chronic inflammation
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3794
  contributor:
    fullname: P Miossec
– volume: 454
  start-page: 350
  year: 2008
  ident: ref20
  article-title: IL-21 and TGFβ are required for differentiation of human TH17 cells
  publication-title: Nature
  doi: 10.1038/nature07021
  contributor:
    fullname: L Yang
– volume: 138
  start-page: 271
  year: 2009
  ident: ref16
  article-title: CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
  publication-title: Cell
  doi: 10.1016/j.cell.2009.05.046
  contributor:
    fullname: S Jaiswal
– volume: 7
  start-page: e47286
  year: 2012
  ident: ref9
  article-title: Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0047286
  contributor:
    fullname: Y Feng
– volume: 25
  start-page: 658
  year: 2005
  ident: ref7
  article-title: Leukocytosis and ischemic vascular disease morbidity and mortality: Is it time to intervene?
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000156877.94472.a5
  contributor:
    fullname: BS Coller
– volume: 22
  start-page: 285
  year: 2005
  ident: ref18
  article-title: Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.01.011
  contributor:
    fullname: MA Stark
– volume: 125
  start-page: 440
  year: 2012
  ident: ref2
  article-title: Evidence-based use of statins for primary prevention of cardiovascular disease
  publication-title: Am J Med
  doi: 10.1016/j.amjmed.2011.11.013
  contributor:
    fullname: CM Minder
– volume: 131
  start-page: 994
  year: 2007
  ident: ref4
  article-title: Immunosurveilence by hematopoietic progenitor cells through blood, lymph and peripheral tissues
  publication-title: Cell
  doi: 10.1016/j.cell.2007.09.047
  contributor:
    fullname: S Massberg
– volume: 339
  year: 1998
  ident: ref12
  article-title: Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
  publication-title: N Engl J Med
– volume: 97
  start-page: 1837
  year: 1998
  ident: ref13
  article-title: Prediction of Coronary Heart Disease Using Risk Factor Categories
  publication-title: Circulation
  doi: 10.1161/01.CIR.97.18.1837
  contributor:
    fullname: PWF Wilson
– volume: 11
  start-page: 195
  year: 2012
  ident: ref10
  article-title: Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.04.024
  contributor:
    fullname: M Westerterp
– volume: 115
  start-page: 3886
  year: 2010
  ident: ref8
  article-title: Hypercholesterolemia promotes bone marrow mobilization by perturbing the SDF-1: CXCR-4 axis
  publication-title: Blood
  doi: 10.1182/blood-2009-08-240580
  contributor:
    fullname: AL Gomes
– volume: 9
  start-page: 641
  year: 2008
  ident: ref21
  article-title: The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
  publication-title: Nat Immunol
  doi: 10.1038/ni.1610
  contributor:
    fullname: N Manel
– volume: 105
  start-page: 199
  year: 2005
  ident: ref5
  article-title: Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction
  publication-title: Blood
  doi: 10.1182/blood-2004-05-1831
  contributor:
    fullname: M Massa
– volume: 183
  start-page: 2593
  year: 1996
  ident: ref17
  article-title: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
  publication-title: J Exp Med
  doi: 10.1084/jem.183.6.2593
  contributor:
    fullname: F Fossiez
– volume: 339
  start-page: 161
  year: 2013
  ident: ref1
  article-title: Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
  publication-title: Science
  doi: 10.1126/science.1230719
  contributor:
    fullname: FK Swirski
– volume: 24
  start-page: 129
  year: 2013
  ident: ref3
  article-title: Hypercholesterolemia links hematopoiesis with atherosclerosis
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2012.10.008
  contributor:
    fullname: O Soehnlein
– volume: 112
  start-page: 1456
  year: 2013
  ident: ref11
  article-title: Deficiency of ABCA1 and ABCG1 in macrophages increases inflammation and accelerates atherosclerosis in mice
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.113.301086
  contributor:
    fullname: M Westerterp
SSID ssj0053866
Score 2.3058221
Snippet Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory...
Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the...
BACKGROUNDHypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the...
BACKGROUND: Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the...
Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the...
SourceID plos
doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e73861
SubjectTerms Acute coronary syndromes
Adult
Antigens, CD34 - immunology
Arteriosclerosis
Atherosclerosis
Blood
Buffy coat
Cardiovascular disease
CD34 antigen
Cell Proliferation
Cell surface
Cells (biology)
Cholesterol
Cholesterol, LDL - physiology
Coronary vessels
Correlation
CXCR4 protein
Cytokines
Cytometry
Differentiation
Enzyme-linked immunosorbent assay
Female
Flow Cytometry
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - physiology
Granulocyte colony-stimulating factor receptors
Hematopoietic stem cells
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Humans
Hypercholesterolemia
Immune system
Inflammation
Interleukin 17
Interleukin-17 - physiology
Leukocyte migration
Leukocytes
Leukocytes (granulocytic)
Lipids
Low density lipoprotein
Male
Medicine
Metabolism
Middle Aged
Monocytes
Neutrophils
Pathogenesis
Phagocytosis
Population studies
Proteins
SDF-1 protein
Statins
Stem cells
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUhp15C04_EbVpU6KElOLElebQ-tptutmUphSSQm5HlMQ2k9lJvoD-_M7J2yZZAL7laEpb0ZkYjJL0nxHsL4FCBp-jXlqnxvkhLi5TItTApsbETj4Ht8zvMr8y36-L6ntQX3wkb6YHHiTv1rshrR6uMyhszYfIWsA1lwVprNA4xRN9MrTdTYwwmLwaID-W0zU8jLifLvkMmy6bifGshCnz9zG962w8P5Zr_Xpm8twbNnoq9mDzKT2On98UOds_EfnTPQX6IHNIfnwtcnC0kR7ZAhNDfyl99w0JdVCuo8snpmTbHcn7xYzrIqNUj490O2XdyyWI-LY7mIV3XUCWUXxdpbuV5Or2YSffnZnghrmZfLqfzNCoqpL5QsEpr8u5G8VUu8lVn0EJrfW1ZJFO7DDNCxrdlUxpbG60Lp2zhfe4nXnlLgBr9Uux2NIeHQmKuoaQWrXeEgwdXm9oA1Lq1pnTaJyJdT2-1HIkzqnB6ZmnDMU5XxXBUEY5EfGYMNnWZ9jp8IGOoojFU_zOGRBwygusfDBXzyWXAw0vE0RrVh4vfbYrJwfjUxHXY34U6Jaufa5uIg9EINp3kh8G5yiARdss8tkaxXdLd_Awk3pr2idT81WMM-7V4ooJKBwU9OBK7q993-IZypVX9NrjFX6tQEIM
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB1BkRCXipaPBkplJA4gFLqxHTs5oZKyXdAWVSqVeoscx2krVcnSbCV-PjOOs7BVxTW2FcdvZjL-eg_gnVbKOK4sRr8mj6W1aZxrh4lco7Lc1TqzzrN9_lCzM_n9PD0PC259OFY5xkQfqOvO0hr5PjGDTTD3TsXnxa-YVKNodzVIaDyERwnXio70ZdOjMRKjLysVrssJnewHdD4tutYRZTYWJ2u_I8_aTyyn111_X8Z59-DkP3-i6VPYDCkkOxgw34IHrt2Gx8dhk3wbtoK_9ux9IJX-8Azc_HDOChLDJWaE7poddzUpd2Etv47PikMhP7LZ6UnRsyDewwZq4551LTshdZ_GDfbCTFtjJce-zeNEs6O4OJ2yg99X_XM4m379WcziILEQ25SrZVyhu9ecznah8xrptGq0rTSpZgozcROEyjZ5nUtdSSFSw3VqbWIzy61GhKV4ARstDucOMJcIlWOLxhonjVWmkpVUqhKNlrkRNoJ4HOlyMTBplH47TeMMZBi5kpApAzIRfCE4VnWJB9s_6G4uyuBWpTVpUhnMQXhSy4yofZSucY4khMBOOBfBDoE5vqAv_5pRBLsjwPcXv10Vo8fRNoppXXfr6-Qkhy50BC8He1h1km4KJ3yiItBrlrL2Fesl7dWlZ_UWOHHE5q_-363X8IR7QQ6Mb2oXNpY3t-4NpkXLas_b_h9d5Qsv
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swED9KB2MvY-0-6q0rGuxhY7jElizZD2O07rJsJKPQBfpmZFneCsHu4hS6_353shyaku3VOmH5PqQ7S_r9AN4qKbWNpcHZr85CYUwSZspiIlfLNLOVSo11aJ_f5WQuvl0mlzswcLZ6BXZbSzvik5ovF8e3v_98woD_6FgbVDR0Or5uG0tQ2DyleuhBjGsjHfKaifW-Aka3lP4C3b96bixQDsefcE8XbbctB71_lPLO2jR-Ao99UslOei_Ygx3b7MPDmd8234c9H8Ede-dhpt8_BTs9m7Kc6HEJK6FdsFlbEZcXSrk_-yw_4-IDm1yc5x3zdD6sBzvuWNuwc-L7qW3vQUw3FQpZ9nUaRop9CfOLMTu5veqewXz8-Uc-CT3pQmiSWK7CEieAKqbTXhjOWlgla2VKRTyaXI_sCI1n6qzKhCoF54mOVWJMZFITG4U2F_w57DaozgNgNuIywx610VZoI3UpSiFlyWslMs1NAOGg6eK6x9Yo3Aabwpqk11xBlim8ZQI4JXOsZQkZ2z1olz8LH2iF0UlUasxK4qgSKYH9SFVh1cQ5x0FYG8ABGXN4QVcQ5NxI0ucFcDgYeHvzm3UzxiBtrOjGtjdOJiOCdK4CeNH7w3qQdHc4ikcyALXhKRtfsdnSXP1yON8cS0ns_vL_w3oFj2JH0YEznjyE3dXyxr7GRGlVHjnf_wtKIREP
  priority: 102
  providerName: Scholars Portal
Title LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis
URI https://www.ncbi.nlm.nih.gov/pubmed/23991206
https://www.proquest.com/docview/1428060553
https://search.proquest.com/docview/1429214637
https://pubmed.ncbi.nlm.nih.gov/PMC3753239
https://doaj.org/article/ca51ba15221d48228067d597333e4aee
http://dx.doi.org/10.1371/journal.pone.0073861
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFH7axoULYvxaYFRG4gBCaZfYsZPjlq0rqJ0qxqTeIsdxRqUuqZZO4s_nPSepVrQTFx9iW7H93rOf7efvA_ispNQ2lAZnvzLxhTGRnyiLjlwp48QWKjbWoX1eycmN-LGIFnsQ9W9hXNC-yZfDanU3rJa_XWzl-s6M-jix0XyWcvSxQ56M9mEfl99-i95Ov2jAUnZv5LgKRp1Ihuu6soSTjdnEDkNPOoOQeI4eLUcOtZ9QTld185TH-W_g5KOVaPwSXnQuJDttm3oIe7Z6BYedkTbsS4ck_fU12On5lKXEgEtwCPWKzeqC6LqwlDu8Z-k5F9_Y5HqeNqxj7GEtnnHD6orNidKntK2SMF0VWMiy71M_UOzST6_H7PTPsnkDN-OLX-nE73gVfBOFcuPnaONFSAFdaLFaWCVLZXJFVJlcn9gTlI8pkyIRKhecRzpUkTGBiU1oFIpV8LdwUOFwHgGzAZcJ1iiNtkIbqXORCylzXiqRaG488PvhzdYtfEbm7tAUbjva4cpIMlknGQ_OSAbbsgR-7T7U97dZpwKZ0VGQa3Q8wqAQMeH5SFXgxohzjo2w1oMjkmD_gyYjVLkTSd3z4LiX6tPZn7bZaGZ0d6IrWz-4MglxoHPlwbtWCbaN7HXJA7WjHju92M1BzXZQ3p0mv__vmh_geegIOnC-k8dwsLl_sB_RTdrkAzSOhcI0TgNKx5cDeHZ2cTX_OXAHD5jORDxwxvMXQ4sXAg
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,12223,12765,21388,24318,27924,27925,31719,31720,33266,33267,33373,33374,33744,33745,43310,43579,43600,43805,53791,53793,73745,74014,74035,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED6xTmK8IDYGCwwwEg8gFNbEjt08oS1b6SCtqv2Q9hY5jgOTpqQsncSfz13iFIomXmNbcfz5Lmef_X0A75SU2obSoPcrY18YE_mxshjIlXIU20KNjG3ZPmdycim-XkVXbsOtcccqe5_YOuqiNrRHfkDMYEOMvSP-efHTJ9Uoyq46CY0N2CTm9GgAm0cns_lZ74vRmqV0F-a4Cg4cPp8WdWWJNBuLg7UfUsvbTzynN3VzX8z579HJv_5F4yfw2AWR7LBDfRse2GoHHk5dmnwHtp3FNuy9o5X-8BRsepyyhORwiRuhvmHTuiDtLqzV7uSz5JiLj2xyPk8a5uR7WEdu3LC6YnPS9yltN2OYrgqsZNlp6geKffGT8zE7_HXd7MLl-OQimfhOZME3USiXfo4GX4R0ugvNVwurZKlMrkg3k-uhHSJYpoyLWKhccB7pUEXGBGZkQqMQY8GfwaDC4dwDZgMuY2xRGm2FNlLnIhdS5rxUItbceOD3I50tOi6NrE2oKVyDdCOXETKZQ8aDI4JjVZeYsNsH9e33zBlWZnQU5BqjkDAoxIjIfaQqcJXEOcdOWOvBHoHZv6DJ_kwkD_Z7gO8vfrsqRpujRIqubH3X1olJEJ0rD55382HVSborHIRD6YFamylrX7FeUl3_aHm9OS4dsfmL_3frDWxNLqZplp7Ovr2ER2Erz4HeTu7DYHl7Z19hkLTMXztL-A2OZg-A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJ028IDY-ljHASDyAUGgSO3bzhLZ0pYOuqhiT9hY5jjMmTUm3dBJ_PneJUyiaeI0dxfF9-Ow7_34A75SU2kbSoPcrE18YE_uJshjIlXKU2EKNjG3RPudyei6-XsQXrv6pcWWVvU9sHXVRGzojHxIyWICxd8yHpSuLWIwnn5c3PjFIUabV0Wk8hC1cFYNoAFtHx_PF994vo2VL6S7PcRUOnaw-LevKEoA2Nocbi1OL4U-Yp9d1c1_8-W8Z5V_r0uQJPHYBJTvsNGAHHthqF7ZPXcp8F3ac9TbsvYOY_vAU7Gw8YylR4xJOQn3NTuuCeLywV3uqz9IxFx_Z9GyRNsxR-bAO6LhhdcUWxPVT2k57mK4K7GTZycwPFfvip2cTdvjrqnkG55PjH-nUd4QLvokjufJzNP4iokovNGUtrJKlMrkiDk2uAxug4EyZFIlQueA81pGKjQnNyERGobwFfw6DCqdzD5gNuUzwjdJoK7SROhe5kDLnpRKJ5sYDv5_pbNnhamRtck3hfqSbuYwkkznJeHBE4lj3JVTs9kF9e5k5I8uMjsNcY0QShYUYEdCPVAXumDjnOAhrPdgjYfYfaLI_SuXBQS_g-5vfrpvR_iipoitb37V9EiJH58qDF50-rAdJ94bDKJAeqA1N2fiLzZbq6meL8c1xG4mv7_9_WG9gG40gm53Mv72ER1HL1IGOTx7AYHV7Z19hvLTKXztD-A1HlxOt
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=LDL+Cholesterol+Modulates+Human+CD34%2B+HSPCs+through+Effects+on+Proliferation+and+the+IL-17+G-CSF+Axis&rft.jtitle=PloS+one&rft.au=Cimato%2C+Thomas+R&rft.au=Palka%2C+Beth+A&rft.au=Lang%2C+Jennifer+K&rft.au=Young%2C+Rebeccah+F&rft.date=2013-08-26&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=8&rft.issue=8&rft.spage=e73861&rft_id=info:doi/10.1371%2Fjournal.pone.0073861&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3055519901
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon