Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis

• Published in: PloS one Vol. 8; no. 10; p. e76451
• Main Authors: Vittal, Ragini, Mickler, Elizabeth A, Fisher, Amanda J, Zhang, Chen, Rothhaar, Katia, Gu, Hongmei, Brown, Krista M, Emtiazjoo, Amir, Lott, Jeremy M, Frye, Sarah B, Smith, Gerald N, Sandusky, George E, Cummings, Oscar W, Wilkes, David S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.10.2013; Public Library of Science (PLoS)
• Subjects: Animal models; Animal tissues; Animals; Antibodies; Autoantibodies - blood; Autoantibodies - immunology; Binding sites; Bleomycin; Bleomycin - adverse effects; Collagen; Collagen (type V); Collagen Type I - immunology; Collagen Type V - administration & dosage; Collagen Type V - genetics; Collagen Type V - immunology; Collagen Type V - metabolism; Consent; Cytokines - biosynthesis; Cytokines - genetics; Deposition; Disease; Disease Models, Animal; Extracellular matrix; Female; Fibrosis; Gene Expression; Gene Expression Regulation - drug effects; Growth factors; Humans; Idiopathic Pulmonary Fibrosis - drug therapy; Idiopathic Pulmonary Fibrosis - genetics; Idiopathic Pulmonary Fibrosis - immunology; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - pathology; Immune Tolerance; Immunity; Immunological tolerance; Inflammation Mediators - metabolism; Interferon; Interleukin 6; Liquid oxygen; Lung diseases; Lungs; Lymphocyte Activation - immunology; Lymphocytes; Medicine; Mice; Nebulizers and Vaporizers; NF-κB protein; Pathogenesis; Pathology; Patients; Pulmonary fibrosis; Pulmonary Fibrosis - drug therapy; Pulmonary Fibrosis - genetics; Pulmonary Fibrosis - immunology; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Scars; Signaling; Smad2 protein; Sp1 protein; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Transcription; Transcription, Genetic - drug effects; Transforming Growth Factor beta - biosynthesis; Transforming Growth Factor beta - genetics; Tumor necrosis factor-α; γ-Interferon; Indiana; United States > US; Indianapolis Indiana

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and matrix deposition. Recent reports highlight an autoimmune component in IPF pathogenesis. We have reported anti-col(V) immunity in IPF patients. The objective of our study was to determi...