Use of Exposure History to Identify Patterns of Immunity to Pneumonia in Bighorn Sheep (Ovis canadensis)

• Published in: PloS one Vol. 8; no. 4; p. e61919
• Main Authors: Plowright, Raina K., Manlove, Kezia, Cassirer, E. Frances, Cross, Paul C., Besser, Thomas E., Hudson, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.04.2013; Public Library of Science (PLoS)
• Subjects: Adults; Age; Aging; Animals; Biology; Disease control; Ecology; Epidemics; Exposure; Female; Frailty; Hazards; Immune response; Immunity; Immunity - immunology; Immunization; Infections; Infectious diseases; Laboratories; Lamb; Male; Mathematics; Medicine; Mortality; Offspring; Outbreaks; Ovis aries; Ovis canadensis; Parasites; Pathogens; Pneumonia; Pneumonia - epidemiology; Pneumonia - immunology; Pneumonia - mortality; Pneumonia - veterinary; Population; Populations; Proportional Hazards Models; Recovery; Recruitment; Sheep; Sheep Diseases - epidemiology; Sheep Diseases - immunology; Sheep Diseases - mortality; Sheep, Bighorn - immunology; Statistical models; Survival; Survival analysis; United States - epidemiology; Veterinary Science; United States; Montana; United States > US; Idaho; Pennsylvania

Individual host immune responses to infectious agents drive epidemic behavior and are therefore central to understanding and controlling infectious diseases. However, important features of individual immune responses, such as the strength and longevity of immunity, can be challenging to characterize...