The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory

• Published in: Genes & development Vol. 31; no. 9; pp. 876 - 888
• Main Authors: Ridings-Figueroa, Rebeca, Stewart, Emma R., Nesterova, Tatyana B., Coker, Heather, Pintacuda, Greta, Godwin, Jonathan, Wilson, Rose, Haslam, Aidan, Lilley, Fred, Ruigrok, Renate, Bageghni, Sumia A., Albadrani, Ghadeer, Mansfield, William, Roulson, Jo-An, Brockdorff, Neil, Ainscough, Justin F.X., Coverley, Dawn
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.05.2017
• Subjects: Animals; Cell Differentiation; Cells, Cultured; Embryo, Mammalian - metabolism; Embryo, Mammalian - pathology; Embryonic Stem Cells - metabolism; Embryonic Stem Cells - pathology; Female; Fibroblasts - metabolism; Fibroblasts - pathology; Gene Expression Regulation; Humans; Lymphoproliferative Disorders - genetics; Lymphoproliferative Disorders - metabolism; Lymphoproliferative Disorders - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Nuclear Proteins - physiology; Research Paper; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Sex Characteristics; X Chromosome - genetics; X Chromosome - metabolism; X Chromosome Inactivation; CIZ1; lymphoproliferative disorder; Xist; nuclear matrix; X-chromosome inactivation

The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) promotes DNA replication in association with cyclins and has been linked to adult and pediatric cancers. Here we show that CIZ1 is highly enriched on the inactive X chromosome (Xi) in mouse and human female cells and is retaine...