The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

• Published in: PLoS pathogens Vol. 17; no. 2; p. e1009300
• Main Authors: Zeng, Yan, Xu, Shuai, Wei, Yanli, Zhang, Xuegang, Wang, Qian, Jia, Yane, Wang, Wanbing, Han, Lu, Chen, Zhaoshan, Wang, Zhengxiang, Zhang, Bo, Chen, Hualan, Lei, Cao-Qi, Zhu, Qiyun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2021; Public Library of Science (PLoS)
• Subjects: Antiviral drugs; Autophagy; Avian flu; Biology and Life Sciences; Cell activation; Fatalities; Gene expression; Genes; Genetics; Genomes; Immune response; Infections; Influenza A; Innate immunity; Interferon; Interferon regulatory factor 3; Kinases; Lymphocytes; Lymphocytes T; Medicine and health sciences; Mutants; Mutation; NF-κB protein; Nonsense mutation; Nucleotides; Pandemics; Pathogens; Phosphorylation; Plasmids; Proteins; RANTES; Research and Analysis Methods; Retinoic acid; RNA-mediated interference; Signal transduction; Signaling; Transcription; Viral infections; Viruses

Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified the PB1 protein of H7N9 virus as a new negative regulator of virus- or poly(I:C)-stimulated IFN...