FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer

• Published in: PloS one Vol. 9; no. 5; p. e96989
• Main Authors: Zhou, Jinhua, Wang, Yunfei, Wang, You, Yin, Xia, He, Yifeng, Chen, Lilan, Wang, Wenwen, Liu, Ting, Di, Wen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.05.2014; Public Library of Science (PLoS)
• Subjects: Apoptosis; Apoptosis - drug effects; Biology and life sciences; Breast cancer; Cancer; Cancer therapies; Cell cycle; Cell growth; Cell Line, Tumor; Chemoresistance; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cisplatin - therapeutic use; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; DNA Repair - drug effects; DNA Repair Enzymes - metabolism; Drug Resistance, Neoplasm; Education; Exodeoxyribonucleases - metabolism; Female; Forkhead Box Protein M1; Forkhead Transcription Factors - metabolism; Gene expression; Gynecology; Hospitals; Humans; Kinases; Laboratories; Medicine; Medicine and Health Sciences; Obstetrics; Oncology; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ovary - drug effects; Ovary - metabolism; Ovary - pathology; Ribonucleic acid; RNA; Sensitivity; siRNA; Toxicity; Transcription factors; Up-Regulation; China

Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional factor FOXM1 has been reported to be overexpressed in ovarian cancer. In this study, we aimed to investigate the potential role of FOXM1 in o...