TGF-βI Regulates Cell Migration through Pluripotent Transcription Factor OCT4 in Endometriosis

• Published in: PloS one Vol. 10; no. 12; p. e0145256
• Main Authors: Au, Heng-Kien, Chang, Jui-Hung, Wu, Yu-Chih, Kuo, Yung-Che, Chen, Yu-Hsi, Lee, Wei-Chin, Chang, Te-Sheng, Lan, Pei-Chi, Kuo, Hung-Chih, Lee, Kha-Liang, Lee, Mei-Tsu, Tzeng, Chii-Ruey, Huang, Yen-Hua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2015; Public Library of Science (PLoS)
• Subjects: Actin; Adult; Biochemistry; Biology; Cadherins; Cadherins - genetics; Cadherins - metabolism; Carcinoma; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement; Chocolate; Cysts; Endometrial cancer; Endometriosis; Endometriosis - metabolism; Endometrium; Female; Gynecology; Hospitals; Humans; Hypoxia; Insulin-like growth factors; Medicine; Middle Aged; Myometrium; N-Cadherin; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Obstetrics; Oct-4 protein; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Ovarian cancer; Patients; Peritoneal fluid; Peritoneum; Pluripotency; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Reproductive health; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signaling; Snail Family Transcription Factors; Stem cells; Stromal cells; Studies; Tissues; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transforming growth factor; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Tumor cell lines; Twist-Related Protein 1 - genetics; Twist-Related Protein 1 - metabolism; Uterine cancer; Wounds; United States > US; Taiwan

Transforming growth factor (TGF-β)/TGF-β receptor signal is known to promote cell migration. Up-regulation of TGF-β in serum/peritoneal fluid and increased levels of pluripotent transcription factor OCT4 in endometriotic tissues are frequently observed in patients with endometriosis. However, the me...