Cellular immune responses in peripheral blood lymphocytes of Giardia infected squirrel monkey (Saimiri boliviensis boliviensis) treated with Fenbendazole

• Published in: PloS one Vol. 13; no. 11; p. e0198497
• Main Authors: Nehete, Pramod N, Wilkerson, Gregory, Nehete, Bharti P, Chitta, Sriram, Ruiz, Julio C, Scholtzova, Henrieta, Williams, Lawrence E, Abee, Christian R, Vanchiere, John A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.11.2018; Public Library of Science (PLoS)
• Subjects: Animals; Antinematodal Agents - pharmacology; Antinematodal Agents - therapeutic use; Biology and Life Sciences; Blood; Breeding of animals; Cancer; CD14 antigen; CD16 antigen; Cell surface; Concanavalin A; Cytokines; Cytokines - blood; Enzyme-linked immunosorbent assay; Eosinophils; Erythrocytes; Fenbendazole - pharmacology; Fenbendazole - therapeutic use; Flow cytometry; Giardia; Giardiasis - drug therapy; Giardiasis - immunology; Giardiasis - veterinary; Hematocrit; Hemoglobin; Immune response; Immune response (cell-mediated); Immune system; Immunity, Cellular - drug effects; Immunology; Infections; Interleukin 1 receptor antagonist; Interleukin 1 receptors; Interleukin 10; Interleukin 12; Interleukin 13; Interleukin 4; Interleukin 6; Laboratory animals; Leukocytes; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lipopolysaccharides; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - immunology; Lymphocytes B; Mammals; Medical research; Medicine and Health Sciences; Monkeys; Monocytes; Parasites; Parasitic diseases; Peripheral blood; Research and Analysis Methods; Saimiri; Sciuridae - immunology; Stimulation; Surface markers; γ-Interferon; Louisiana; New York; United States > US; Texas

Cellular immune responses were tested to determine the effect of fenbendazole on the function of lymphocytes from Bolivian squirrel monkeys (Samiri boliviensis boliviensis). Giardia-infected squirrel monkeys were treated with commercially available fenbendazole (FBZ)-medicated monkey chow. Immune re...