Cerebrospinal Fluid (CSF) CD8+ T-Cells That Express Interferon-Gamma Contribute to HIV Associated Neurocognitive Disorders (HAND)

• Published in: PloS one Vol. 10; no. 2; p. e0116526
• Main Authors: Schrier, Rachel D., Hong, Suzi, Crescini, Melanie, Ellis, Ronald, Pérez-Santiago, Josué, Spina, Celsa, Letendre, Scott
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.02.2015; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Aged; AIDS; Anti-Retroviral Agents - therapeutic use; Antigens, CD - cerebrospinal fluid; Antigens, Differentiation, Myelomonocytic - cerebrospinal fluid; Blood; Brain; CD163 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell activation; Central nervous system; Cerebrospinal fluid; Cognition; Cognition Disorders - etiology; Cognition Disorders - pathology; Cognitive ability; Cohort Studies; Correlation; Cytokines; Cytolytic activity; Dementia; Demography; Disorders; Epidemiology; Female; Gene expression; HIV; HIV Infections - complications; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Infections; Interferon; Interferon-gamma - cerebrospinal fluid; Interleukin 2; Interleukin-2 - cerebrospinal fluid; Lymphocytes; Lymphocytes T; Lysosomal-Associated Membrane Protein 1 - metabolism; Macrophages; Male; Medicine; Middle Aged; Monocytes; Mortality; Pathogenesis; Peripheral blood; Receptors, Cell Surface; Ribonucleic acid; RNA; RNA, Viral - cerebrospinal fluid; Severity of Illness Index; Surveillance; T cell receptors; Tumor Necrosis Factor-alpha - cerebrospinal fluid; Tumor necrosis factor-α; Virus Replication; Young Adult; γ-Interferon; La Jolla California; United States > US; California

HIV associated neurocognitive disorders (HAND) continue to affect cognition and everyday functioning despite anti-retroviral treatment (ART). Previous studies focused on mechanisms related to monocyte/macrophage mediated inflammation. However, in the ART era, there is increasing evidence for the inv...