Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

• Published in: PLoS pathogens Vol. 17; no. 12; p. e1010085
• Main Authors: Uraki, Ryuta, Imai, Masaki, Ito, Mutsumi, Shime, Hiroaki, Odanaka, Mizuyu, Okuda, Moe, Kawaoka, Yoshihiro, Yamazaki, Sayuri
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2021; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Adaptive Immunity - immunology; Adjuvants; Animals; Antibodies; Antigen presentation; Antigen Presentation - immunology; Antigens; Antigens, Viral - immunology; Autoimmune diseases; Biology and life sciences; CD25 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell-mediated immunity; Chlorocebus aethiops; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; Dendritic cells; Dendritic Cells - immunology; Depletion; Experiments; Female; Forkhead Transcription Factors - immunology; Foxp3 protein; Germinal Center - immunology; Humans; Humoral immunity; Immune response; Immune Tolerance; Immunity; Immunity (cell-mediated); Immunological tolerance; Immunology; Immunoregulation; Interferon; Interleukin 2; Interleukin 2 receptors; Lymph nodes; Lymphatic system; Lymphocytes; Lymphocytes T; Maturation; Medicine and health sciences; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Proteins; Research and Analysis Methods; Rodents; SARS-CoV-2 - immunology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike protein; T-Lymphocytes, Regulatory - immunology; Vaccines; Vero Cells; γ-Interferon

Regulatory T (Treg) cells, which constitute about 5–10% of CD4 + T cells expressing Foxp3 transcription factor and CD25(IL-2 receptor α chain), are key regulators in controlling immunological self-tolerance and various immune responses. However, how Treg cells control antigen-specific immunity to se...