Low Serum Acylated Ghrelin Levels are Associated with the Development of Cardiovascular Disease in Hemodialysis Patients

• Published in: Internal Medicine Vol. 49; no. 19; pp. 2057 - 2064
• Main Authors: Chou, Chia-Chi, Bai, Chyi-Huey, Tsai, Shiow-Chwen, Wu, Mai-Szu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2010
• Subjects: Acylation; Aged; cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Cohort Studies; Endothelial Cells - physiology; Female; ghrelin; Ghrelin - blood; Ghrelin - chemistry; Ghrelin - deficiency; hemodialysis; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Renal Dialysis - adverse effects; Risk Factors

Background Ghrelin has a protective effect on endothelial cells. Endothelial cell dysfunction is associated with cardiovascular disease (CVD) and CVD remains the leading cause of morbidity in hemodialysis (HD) patients. Acylated ghrelin (A-Ghr) is the functional form of ghrelin, so we hypothesized t...