Circulating Levels of Human salusin-β,a Potent Hemodynamic and Atherogenesis Regulator

• Published in: PloS one Vol. 8; no. 10; p. e76714
• Main Authors: Fujimoto, Kazumi, Hayashi, Akinori, Kamata, Yuji, Ogawa, Akifumi, Watanabe, Takuya, Ichikawa, Raishi, Iso, Yoshitaka, Koba, Shinji, Kobayashi, Youichi, Koyama, Takatoshi, Shichiri, Masayoshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.10.2013; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Antibodies; Antibodies - blood; Antibodies - chemistry; Arteriosclerosis; Atherogenesis; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - physiopathology; Bioassays; Bioinformatics; Biological assays; Blood plasma; Cardiology; Cardiovascular disease; Cerebrovascular Disorders - blood; Cerebrovascular Disorders - physiopathology; Chickens; Chromatography; Chromatography, High Pressure Liquid; Circadian Rhythm - physiology; Circadian rhythms; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - physiopathology; Coronary vessels; Diabetes; Diabetes insipidus; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - physiopathology; Disease control; Endocrinology; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Female; Glassware; Heart diseases; Hematology; Hemodynamics; Hemodynamics - physiology; High performance liquid chromatography; Humans; Hypertension; Hypopituitarism - blood; Hypopituitarism - physiopathology; Immunization; Infusion; Intercellular Signaling Peptides and Proteins - isolation & purification; Intercellular Signaling Peptides and Proteins - physiology; Laboratories; Life sciences; Liquid chromatography; Macrophages; Male; Medicine; Metabolism; Middle Aged; Neuroendocrine system; Peptides; Pharmacy; Physiology; Polyclonal antibodies; Posture; Rabbits; Reference Values; Rodents; Smoking; Urine; Vascular diseases; Vasopressin; Womens health; United States > US; Japan

Using bioinformatics analysis, we previously identified salusin-β, an endogenous bioactive peptide with diverse physiological activities. Salusin-β is abundantly expressed in the neuroendocrine system and in systemic endocrine cells/macrophages. Salusin-β acutely regulates hemodynamics and chronical...