Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection

The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transc...

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Published inPloS one Vol. 8; no. 6; p. e66136
Main Authors Waithman, Jason, Zanker, Damien, Xiao, Kun, Oveissi, Sara, Wylie, Ben, Ng, Royce, Tögel, Lars, Chen, Weisan
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 04.06.2013
Public Library of Science (PLoS)
Subjects
Acute Disease
Animals
Antigens
Antigens, CD - metabolism
Biology
Cancer
CD103 antigen
CD11b antigen
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell migration
Cell Movement - immunology
Childrens health
Cytotoxicity
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Ethics
Female
Humans
Immunity
Infections
Influenza
Influenza A
Influenza A virus - physiology
Integrin alpha Chains - metabolism
Lymph nodes
Lymphatic system
Lymphocytes
Lymphocytes T
Major histocompatibility complex
Medical research
Medicine
Mice
Orthomyxoviridae Infections - immunology
Science
Studies
T cell receptors
Viral infections
Viruses
Australia
Victoria Australia
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Abstract The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8(+) and migratory CD103(+)CD11b(-) DCs and we found both of these subtypes could efficiently stimulate anti-IAV TCD8+. Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8(+) DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8(+) DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.
AbstractList The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8 + T lymphocyte (T CD8+ ) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8 + and migratory CD103 + CD11b − DCs and we found both of these subtypes could efficiently stimulate anti-IAV T CD8+ . Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8 + DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8 + DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.
The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8(+) and migratory CD103(+)CD11b(-) DCs and we found both of these subtypes could efficiently stimulate anti-IAV TCD8+. Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8(+) DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8(+) DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.
The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8+ T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8+ and migratory CD103+CD11b− DCs and we found both of these subtypes could efficiently stimulate anti-IAV TCD8+. Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8+ DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8+ DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.
The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8(+) and migratory CD103(+)CD11b(-) DCs and we found both of these subtypes could efficiently stimulate anti-IAV TCD8+. Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8(+) DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8(+) DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription factor is required for the development of lymph node resident CD8(+) and migratory CD103(+)CD11b(-) DCs and we found both of these subtypes could efficiently stimulate anti-IAV TCD8+. Using a similar ex vivo approach, many publications on this subject matter excluded a role for resident, non-migratory CD8(+) DC. We postulate the differences reported can partially be explained by how DC are phenotyped, namely the use of MHC class II to segregate subtypes. Our results show that resident CD8(+) DC upregulate this marker during IAV infection and we advise against its use when isolating DC subtypes.
Author Wylie, Ben
Waithman, Jason
Xiao, Kun
Oveissi, Sara
Ng, Royce
Zanker, Damien
Chen, Weisan
Tögel, Lars
AuthorAffiliation 2 Ludwig Institute for Cancer Research (Melbourne-Austin Branch), Melbourne, Victoria, Australia
3 School of Molecular Science, La Trobe University, Melbourne, Victoria, Australia
1 Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Massachusetts General Hospital, United States of America
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Cites_doi 10.1084/jem.20071365
10.1016/j.immuni.2006.04.017
10.1084/jem.176.1.47
10.1172/JCI60659
10.1084/jem.154.1.168
10.1073/pnas.0402644101
10.1038/ni.1724
10.1371/journal.pone.0025660
10.1038/nature11531
10.1038/nri746
10.1016/0092-8674(86)90019-X
10.1016/S1074-7613(00)80447-1
10.1073/pnas.1206039109
10.1038/ni.1838
10.4049/jimmunol.182.1.29
10.1038/32588
10.4049/jimmunol.1100987
10.4049/jimmunol.179.7.4535
10.4049/jimmunol.176.4.2161
10.1016/j.jim.2012.10.012
10.1371/journal.ppat.1002345
10.1084/jem.20091627
10.1128/JVI.74.8.3486-3493.2000
10.1038/nm1643
10.1126/science.1164206
10.1371/journal.pone.0004204
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2013 Waithman et al 2013 Waithman et al
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: JW DZ KX WC. Performed the experiments: JW DZ KX SO BW RN LT. Analyzed the data: JW DZ KX SO BW RN LT. Contributed reagents/materials/analysis tools: JW DZ WC. Wrote the paper: JW.
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References ref13
GT Belz (ref6) 2004; 101
BT Edelson (ref21) 2011; 6
J Waithman (ref19) 2007; 179
SS Sung (ref5) 2006; 176
BT Edelson (ref16) 2010; 207
ref18
GT Belz (ref24) 2000; 74
A Porgador (ref26) 1997; 6
AW Ho (ref11) 2011; 187
S Bedoui (ref20) 2009; 10
A Ballesteros-Tato (ref10) 2010; 11
RS Allan (ref25) 2006; 25
AR Townsend (ref23) 1986; 44
E Ingulli (ref8) 2009; 182
RM Steinman (ref1) 2007; 13
MC Nussenzweig (ref3) 1981; 154
ref22
TS Kim (ref9) 2009; 4
(ref17); 3
K Shortman (ref2) 2002; 2
RA Langlois (ref27) 2012; 109
B Moltedo (ref12) 2011; 7
J Banchereau (ref14) 1998; 392
D Vremec (ref4) 1992; 176
CH GeurtsvanKessel (ref7) 2008; 205
K Hildner (ref15) 2008; 322
2420472 - Cell. 1986 Mar 28;44(6):959-68
20098442 - Nat Immunol. 2010 Mar;11(3):216-24
19109130 - J Immunol. 2009 Jan 1;182(1):29-33
20351058 - J Exp Med. 2010 Apr 12;207(4):823-36
16860764 - Immunity. 2006 Jul;25(1):153-62
10729122 - J Virol. 2000 Apr;74(8):3486-93
17878350 - J Immunol. 2007 Oct 1;179(7):4535-41
15163797 - Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5
23076333 - Virulence. 2012 Nov 15;3(7):603-8
22778433 - Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12117-22
17917664 - Nat Med. 2007 Oct;13(10):1155-9
23098837 - J Immunol Methods. 2013 Jan 31;387(1-2):173-80
9521319 - Nature. 1998 Mar 19;392(6673):245-52
22992524 - Nature. 2012 Oct 25;490(7421):502-7
18591406 - J Exp Med. 2008 Jul 7;205(7):1621-34
19145246 - PLoS One. 2009;4(1):e4204
19008445 - Science. 2008 Nov 14;322(5904):1097-100
9208844 - Immunity. 1997 Jun;6(6):715-26
19349986 - Nat Immunol. 2009 May;10(5):488-95
7252426 - J Exp Med. 1981 Jul 1;154(1):168-87
23041628 - J Clin Invest. 2012 Nov;122(11):4037-47
22072965 - PLoS Pathog. 2011 Nov;7(11):e1002345
22065991 - PLoS One. 2011;6(10):e25660
1613465 - J Exp Med. 1992 Jul 1;176(1):47-58
11913066 - Nat Rev Immunol. 2002 Mar;2(3):151-61
22043017 - J Immunol. 2011 Dec 1;187(11):6011-21
16455972 - J Immunol. 2006 Feb 15;176(4):2161-72
References_xml – volume: 205
  start-page: 1621
  year: 2008
  ident: ref7
  article-title: Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells
  publication-title: J Exp Med
  doi: 10.1084/jem.20071365
– volume: 25
  start-page: 153
  year: 2006
  ident: ref25
  article-title: Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.04.017
– volume: 176
  start-page: 47
  year: 1992
  ident: ref4
  article-title: The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells
  publication-title: J Exp Med
  doi: 10.1084/jem.176.1.47
– ident: ref13
  doi: 10.1172/JCI60659
– volume: 154
  start-page: 168
  year: 1981
  ident: ref3
  article-title: Studies of the cell surface of mouse dendritic cells and other leukocytes
  publication-title: J Exp Med
  doi: 10.1084/jem.154.1.168
– volume: 101
  start-page: 8670
  year: 2004
  ident: ref6
  article-title: Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0402644101
– volume: 10
  start-page: 488
  year: 2009
  ident: ref20
  article-title: Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
  publication-title: Nat Immunol
  doi: 10.1038/ni.1724
– volume: 6
  start-page: e25660
  year: 2011
  ident: ref21
  article-title: Batf3-dependent CD11blow/− peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0025660
– ident: ref22
  doi: 10.1038/nature11531
– volume: 2
  start-page: 151
  year: 2002
  ident: ref2
  article-title: Mouse and human dendritic cell subtypes
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri746
– volume: 44
  start-page: 959
  year: 1986
  ident: ref23
  article-title: The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
  publication-title: Cell
  doi: 10.1016/0092-8674(86)90019-X
– volume: 6
  start-page: 715
  year: 1997
  ident: ref26
  article-title: Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80447-1
– volume: 109
  start-page: 12117
  year: 2012
  ident: ref27
  article-title: Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1206039109
– volume: 11
  start-page: 216
  year: 2010
  ident: ref10
  article-title: Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza
  publication-title: Nat Immunol
  doi: 10.1038/ni.1838
– volume: 182
  start-page: 29
  year: 2009
  ident: ref8
  article-title: Cutting edge: antigen presentation to CD8 T cells after influenza A virus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.182.1.29
– volume: 392
  start-page: 245
  year: 1998
  ident: ref14
  article-title: Dendritic cells and the control of immunity
  publication-title: Nature
  doi: 10.1038/32588
– volume: 187
  start-page: 6011
  year: 2011
  ident: ref11
  article-title: Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1100987
– volume: 179
  start-page: 4535
  year: 2007
  ident: ref19
  article-title: Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.7.4535
– volume: 176
  start-page: 2161
  year: 2006
  ident: ref5
  article-title: A major lung CD103 (αE)-β7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.4.2161
– volume: 3
  ident: ref17
– ident: ref18
  doi: 10.1016/j.jim.2012.10.012
– volume: 7
  start-page: e1002345
  year: 2011
  ident: ref12
  article-title: Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002345
– volume: 207
  start-page: 823
  year: 2010
  ident: ref16
  article-title: Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
  publication-title: J Exp Med
  doi: 10.1084/jem.20091627
– volume: 74
  start-page: 3486
  year: 2000
  ident: ref24
  article-title: A previously unrecognized H-2Db-restricted peptide prominent in the primary influenza A virus-specific CD8+ T-cell response is much less apparent following secondary challenge
  publication-title: J Virol
  doi: 10.1128/JVI.74.8.3486-3493.2000
– volume: 13
  start-page: 1155
  year: 2007
  ident: ref1
  article-title: Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system
  publication-title: Nat Med
  doi: 10.1038/nm1643
– volume: 322
  start-page: 1097
  year: 2008
  ident: ref15
  article-title: Batf3 deficiency reveals a critical role for CD8α+ dendritic cells in cytotoxic T cell immunity
  publication-title: Science
  doi: 10.1126/science.1164206
– volume: 4
  start-page: e4204
  year: 2009
  ident: ref9
  article-title: Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0004204
– reference: 16455972 - J Immunol. 2006 Feb 15;176(4):2161-72
– reference: 23076333 - Virulence. 2012 Nov 15;3(7):603-8
– reference: 17917664 - Nat Med. 2007 Oct;13(10):1155-9
– reference: 11913066 - Nat Rev Immunol. 2002 Mar;2(3):151-61
– reference: 15163797 - Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5
– reference: 19109130 - J Immunol. 2009 Jan 1;182(1):29-33
– reference: 10729122 - J Virol. 2000 Apr;74(8):3486-93
– reference: 19145246 - PLoS One. 2009;4(1):e4204
– reference: 20098442 - Nat Immunol. 2010 Mar;11(3):216-24
– reference: 22992524 - Nature. 2012 Oct 25;490(7421):502-7
– reference: 16860764 - Immunity. 2006 Jul;25(1):153-62
– reference: 19349986 - Nat Immunol. 2009 May;10(5):488-95
– reference: 22778433 - Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12117-22
– reference: 7252426 - J Exp Med. 1981 Jul 1;154(1):168-87
– reference: 23041628 - J Clin Invest. 2012 Nov;122(11):4037-47
– reference: 2420472 - Cell. 1986 Mar 28;44(6):959-68
– reference: 1613465 - J Exp Med. 1992 Jul 1;176(1):47-58
– reference: 9521319 - Nature. 1998 Mar 19;392(6673):245-52
– reference: 18591406 - J Exp Med. 2008 Jul 7;205(7):1621-34
– reference: 19008445 - Science. 2008 Nov 14;322(5904):1097-100
– reference: 9208844 - Immunity. 1997 Jun;6(6):715-26
– reference: 23098837 - J Immunol Methods. 2013 Jan 31;387(1-2):173-80
– reference: 22043017 - J Immunol. 2011 Dec 1;187(11):6011-21
– reference: 17878350 - J Immunol. 2007 Oct 1;179(7):4535-41
– reference: 22072965 - PLoS Pathog. 2011 Nov;7(11):e1002345
– reference: 20351058 - J Exp Med. 2010 Apr 12;207(4):823-36
– reference: 22065991 - PLoS One. 2011;6(10):e25660
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Snippet The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and...
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StartPage e66136
SubjectTerms Acute Disease
Animals
Antigens
Antigens, CD - metabolism
Biology
Cancer
CD103 antigen
CD11b antigen
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell migration
Cell Movement - immunology
Childrens health
Cytotoxicity
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Ethics
Female
Humans
Immunity
Infections
Influenza
Influenza A
Influenza A virus - physiology
Integrin alpha Chains - metabolism
Lymph nodes
Lymphatic system
Lymphocytes
Lymphocytes T
Major histocompatibility complex
Medical research
Medicine
Mice
Orthomyxoviridae Infections - immunology
Science
Studies
T cell receptors
Viral infections
Viruses
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Title Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection
URI https://www.ncbi.nlm.nih.gov/pubmed/23750278
https://www.proquest.com/docview/1364760712
https://www.proquest.com/docview/1366580384
https://pubmed.ncbi.nlm.nih.gov/PMC3672151
https://doaj.org/article/73049e20e26f4f998edfca36700bade5
http://dx.doi.org/10.1371/journal.pone.0066136
Volume 8
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