Asthma Is Associated with Multiple Alterations in Anti-Viral Innate Signalling Pathways

• Published in: PloS one Vol. 9; no. 9; p. e106501
• Main Authors: Pritchard, Antonia L., White, Olivia J., Burel, Julie G., Carroll, Melanie L., Phipps, Simon, Upham, John W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.09.2014; Public Library of Science (PLoS)
• Subjects: Abnormalities; Adult; Allergies; Alterations; Animals; Antiviral agents; Asthma; Asthma - genetics; Asthma - immunology; Asthma - virology; Biology and Life Sciences; Bone marrow; Cell migration; Chemical synthesis; Cytokines; Dendritic cells; Dendritic Cells - immunology; Female; Gene expression; Humans; Immune response; Immune system; Immunity; Immunity, Innate; Immunology; Infections; Innate immunity; Interferon; Interferon regulatory factor 1; Interferon regulatory factor 7; Interferon-alpha - biosynthesis; Interferon-alpha - genetics; Interferon-beta - biosynthesis; Interferon-beta - genetics; Kinases; Leukocytes (mononuclear); Male; Medical research; Medicine; Medicine and Health Sciences; Molecular biology; Molecular chains; mRNA; NF-κB protein; Pathways; Peripheral blood mononuclear cells; Proteins; Receptors; Respiratory tract; Rhinovirus; Rhinovirus - genetics; Rhinovirus - physiology; Ribonucleic acid; RNA; RNA, Viral - metabolism; Signal transduction; Signal Transduction - immunology; Signaling; Stat1 protein; TLR7 protein; Toll-like receptors; Toll-Like Receptors - metabolism; Transcriptional Activation - immunology; Viral infections; Australia

Human rhinovirus (HRV) infection is a major trigger for asthma exacerbations. Anti-viral immunity appears to be abnormal in asthma, with immune dysfunction reported in both airway structural cells and migratory, bone marrow derived cells. Though decreased capacity to produce anti-viral interferons (...