The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3 - Zhu, Jian; Sun, Ruping; Sun, Kaiqiang; Yan, Chen; Jiang, Jialin; Kong, Fanqi; Shi, Jiangang (Redox biology, 2023)
Keywords: De-ubiquitination; Deubiquitinating Enzymes - metabolism; Ferroptosis - genetics; Glutathione - metabolism; Humans; Intervertebral Disc Degeneration - metabolism; IVDD; Nucleus Pulposus - metabolism; Nucleus Pulposus - pathology; Oxidative Stress - physiology; Oxidative stress-induced ferroptosis; Pain - metabolism; Research Paper; Sirt3; Sirtuin 3 - metabolism; Thiolester Hydrolases - metabolism; Thiolester Hydrolases - therapeutic use; USP11; Sirt3; De-ubiquitination; USP11; Oxidative stress-induced ferroptosis; IVDD