Metabolic characteristics of benign and malignant pulmonary nodules and establishment of invasive lung adenocarcinoma model by high-resolution mass spectrometry

• Published in: BMC cancer Vol. 25; no. 1; pp. 844 - 12
• Main Authors: Zhang, Junbao, Zhang, Zhihan, Liu, Yuying, Hou, Yanyi, Pang, Ruifang, Wang, Yuenan, Xu, Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.05.2025; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - blood; Adenocarcinoma of Lung - diagnosis; Adenocarcinoma of Lung - metabolism; Adenocarcinoma of Lung - pathology; Adult; Aged; Analysis; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - metabolism; Care and treatment; Diagnosis; Female; High-resolution mass spectrometry; Humans; Invasiveness; Lung adenocarcinoma; Lung cancer; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung nodules; Male; Malignancy; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Medical screening; Metabolites; Metabolomics; Metabolomics - methods; Metastases; Middle Aged; Mortality; Multiple Pulmonary Nodules - diagnosis; Multiple Pulmonary Nodules - metabolism; Multiple Pulmonary Nodules - pathology; Multivariate analysis; Noninvasive metabolomic model; Prediction models; Risk factors; Solitary Pulmonary Nodule - diagnosis; Solitary Pulmonary Nodule - metabolism; Solitary Pulmonary Nodule - pathology; Tumor staging; China; Metabolomics; High-resolution mass spectrometry; Lung adenocarcinoma; Lung nodules; Noninvasive metabolomic model

Increasing pulmonary nodule presentations in lung adenocarcinoma patients reveal diagnostic limitations of CT-based invasiveness assessment. The critical unmet need lies in developing non-invasive biomarkers differentiating invasive adenocarcinoma from premalignant lesions and benign nodules, while...