The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets - Steiner, Normann; Müller, Udo; Hajek, Roman; Sevcikova, Sabina; Borjan, Bojana; Jöhrer, Karin; Göbel, Georg; Pircher, Andreas; Gunsilius, Eberhard (PloS one, 2018)
Keywords: Aged; Aged, 80 and over; Amines; Amino acids; Angiogenesis; Benign monoclonal gammopathy; Biogenic amines; Biology; Biology and Life Sciences; Biomarkers; Blood; Blood plasma; Bone marrow; Breast cancer; Cancer; Carnitine; Case-Control Studies; Creatinine; Dioxygenase; Disease; Energy metabolism; Ethics; Female; Hematology; Hexoses; Humans; Immunology; Immunoregulation; Immunotherapy; Inflammation; Internal medicine; Laboratories; Lecithin; Life sciences; Lipid metabolism; Male; Mass spectrometry; Mass spectroscopy; Medical research; Medicine; Medicine and Health Sciences; Metabolic Networks and Pathways; Metabolism; Metabolites; Metabolome; Metabolomics; Metabolomics - methods; Middle Aged; Monoclonal gammopathy; Monoclonal Gammopathy of Undetermined Significance - blood; Multiple myeloma; Multiple Myeloma - blood; Oncology; Patients; Peripheral blood; Phosphatidylcholine; Plasma levels; Target recognition; Therapeutic applications; Czech Republic; Austria