Reproducibility of [18F]MK-6240 kinetics in brain studies with shortened dynamic PET protocol in healthy/cognitively normal subjects

• Published in: EJNMMI physics Vol. 11; no. 1; pp. 79 - 11
• Main Authors: Schuck, Phelipi N., Wang, Xiuyuan H., Tanzi, Emily B., Xie, Sally, Li, Yi, Nehmeh, Sadek A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 27.09.2024; Springer Nature B.V; SpringerOpen
• Subjects: [18F]MK-6240; Applied and Technical Physics; Brain; Computational Mathematics and Numerical Analysis; Datasets; Engineering; Error analysis; Image acquisition; Imaging; Kinetic modeling; Medicine; Medicine & Public Health; Nuclear Medicine; Original Research; PET; Positron emission; Protocol; Radioactive tracers; Radiology; Reproducibility; F]MK-6240; [; Kinetic modeling; Protocol; PET; [18F]MK-6240

Background [ 18 F]MK-6240 is a neurofibrillary tangles PET radiotracer that has been broadly used in aging and Alzheimer’s disease (AD) studies. Majority of [ 18 F]MK-6240 PET studies use dynamic acquisitions longer than 60 min to assess the tracer kinetic parameters. As of today, no consensus has b...