Downregulated E-Cadherin Expression Indicates Worse Prognosis in Asian Patients with Colorectal Cancer: Evidence from Meta-Analysis

• Published in: PloS one Vol. 8; no. 7; p. e70858
• Main Authors: He, Xin, Chen, Zhigang, Jia, Minyue, Zhao, Xiaoying
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.07.2013; Public Library of Science (PLoS)
• Subjects: Asian People - genetics; Biology; Cadherins - genetics; Cell adhesion & migration; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Down-Regulation; E-cadherin; Epithelial-Mesenchymal Transition; Gastroenterology; Gene Expression Regulation, Neoplastic; Genotype & phenotype; Hematology; Hospitals; Humans; Immunohistochemistry; Medical ethics; Medical prognosis; Medicine; Mesenchyme; Meta-analysis; Metastases; Metastasis; Neoplasm Grading; Neoplasm Staging; Odds Ratio; Patients; Prognosis; Proportional Hazards Models; Publication Bias; Quality; Studies; Tumors

Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression and aggressiveness of colorectal carcinoma. E-cadherin is the best-characterized molecular marker of EMT, but its prognostic significance for patients with CRC remains inconclusive. Eligible studies were searched from th...