Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis

• Published in: Neurotherapeutics Vol. 20; no. 2; pp. 464 - 483
• Main Authors: Zohny, Sohir M., Habib, Mohamed Z., Mohamad, Magda I., Elayat, Wael M., Elhossiny, Reham M., El-Salam, Mohamed F. Abd, Hassan, Ghada A.M., Aboul-Fotouh, Sawsan
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.03.2023; Springer International Publishing; Springer Nature B.V
• Subjects: Animal models; Animals; Apoptosis; Aripiprazole; Aripiprazole - adverse effects; Astrocyte; Autism; Autism spectrum disorder; Autism Spectrum Disorder - chemically induced; Autism Spectrum Disorder - drug therapy; Autistic Disorder - chemically induced; Autistic Disorder - drug therapy; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Cognitive ability; Cognitive dysfunction; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - complications; Cognitive Dysfunction - drug therapy; Cyclic AMP response element-binding protein; Disease Models, Animal; Female; gamma-Aminobutyric Acid - pharmacology; Gene expression; Glutamate; Glutamatergic transmission; Glutamates - adverse effects; Glutamic acid transporter; Hippocampus; Homeostasis; Male; Maze learning; Memantine; Memantine - adverse effects; Neurobiology; Neurofibrillary tangles; Neurology; Neurosciences; Neurosurgery; Original; Original Article; Pregnancy; Protein structure; Proteins; Rats; Rats, Wistar; Sodium valproate; Spatial discrimination learning; Stereotyped behavior; Therapeutic targets; Valproic Acid; γ-Aminobutyric acid; Memantine; Astrocyte; Aripiprazole; Glutamate; Autism spectrum disorder; Cognitive dysfunction

Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role...